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Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

Overview of attention for article published in Diabetologia, June 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

news
1 news outlet
patent
30 patents
facebook
1 Facebook page

Citations

dimensions_citation
176 Dimensions

Readers on

mendeley
235 Mendeley
Title
Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice
Published in
Diabetologia, June 2013
DOI 10.1007/s00125-013-2955-4
Pubmed ID
Authors

Jennifer E. Bruin, Alireza Rezania, Jean Xu, Kavitha Narayan, Jessica K. Fox, John J. O’Neil, Timothy J. Kieffer

Abstract

Islet transplantation is a promising cell therapy for patients with diabetes, but it is currently limited by the reliance upon cadaveric donor tissue. We previously demonstrated that human embryonic stem cell (hESC)-derived pancreatic progenitor cells matured under the kidney capsule in a mouse model of diabetes into glucose-responsive insulin-secreting cells capable of reversing diabetes. However, the formation of cells resembling bone and cartilage was a major limitation of that study. Therefore, we developed an improved differentiation protocol that aimed to prevent the formation of off-target mesoderm tissue following transplantation. We also examined how variation within the complex host environment influenced the development of pancreatic progenitors in vivo.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 235 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 <1%
Egypt 1 <1%
Singapore 1 <1%
Belgium 1 <1%
United States 1 <1%
Unknown 230 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 59 25%
Researcher 40 17%
Student > Bachelor 30 13%
Student > Master 26 11%
Student > Postgraduate 11 5%
Other 35 15%
Unknown 34 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 64 27%
Agricultural and Biological Sciences 48 20%
Medicine and Dentistry 35 15%
Engineering 20 9%
Immunology and Microbiology 5 2%
Other 20 9%
Unknown 43 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2023.
All research outputs
#3,160,989
of 24,363,506 outputs
Outputs from Diabetologia
#1,533
of 5,250 outputs
Outputs of similar age
#24,153
of 181,753 outputs
Outputs of similar age from Diabetologia
#10
of 46 outputs
Altmetric has tracked 24,363,506 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,250 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 181,753 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.