Report for: Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

Title	Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice
Published in	Diabetologia, June 2013
DOI	10.1007/s00125-013-2955-4
Pubmed ID	23771205
Authors	Jennifer E. Bruin, Alireza Rezania, Jean Xu, Kavitha Narayan, Jessica K. Fox, John J. O’Neil, Timothy J. Kieffer
Abstract	Islet transplantation is a promising cell therapy for patients with diabetes, but it is currently limited by the reliance upon cadaveric donor tissue. We previously demonstrated that human embryonic stem cell (hESC)-derived pancreatic progenitor cells matured under the kidney capsule in a mouse model of diabetes into glucose-responsive insulin-secreting cells capable of reversing diabetes. However, the formation of cells resembling bone and cartilage was a major limitation of that study. Therefore, we developed an improved differentiation protocol that aimed to prevent the formation of off-target mesoderm tissue following transplantation. We also examined how variation within the complex host environment influenced the development of pancreatic progenitors in vivo.

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Mendeley readers

The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Australia	1	<1%
Egypt	1	<1%
United States	1	<1%
Belgium	1	<1%
Singapore	1	<1%
Unknown	154	97%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	43	27%
Researcher	31	19%
Student > Master	23	14%
Student > Bachelor	20	13%
Professor	8	5%
Other	34	21%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	46	29%
Agricultural and Biological Sciences	45	28%
Medicine and Dentistry	28	18%
Engineering	13	8%
Unspecified	13	8%
Other	14	9%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2018.

All research outputs

#3,777,321

of 13,199,565 outputs

Outputs from Diabetologia

#1,704

of 3,814 outputs

Outputs of similar age

#66,047

of 221,649 outputs

Outputs of similar age from Diabetologia

#33

of 62 outputs

Altmetric has tracked 13,199,565 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.

So far Altmetric has tracked 3,814 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one has gotten more attention than average, scoring higher than 54% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,649 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.

We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

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Attention Score in Context