Title |
Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation
|
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Published in |
Molecular Neurodegeneration, January 2013
|
DOI | 10.1186/1750-1326-8-2 |
Pubmed ID | |
Authors |
William A Eimer, Robert Vassar |
Abstract |
Although the mechanism of neuron loss in Alzheimer's disease (AD) is enigmatic, it is associated with cerebral accumulation of Aβ42. The 5XFAD mouse model of amyloid deposition expresses five familial AD (FAD) mutations that are additive in driving Aβ42 overproduction. 5XFAD mice exhibit intraneuronal Aβ42 accumulation at 1.5 months, amyloid deposition at 2 months, and memory deficits by 4 months of age. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 399 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | <1% |
Spain | 3 | <1% |
United Kingdom | 2 | <1% |
Germany | 1 | <1% |
Australia | 1 | <1% |
Canada | 1 | <1% |
Unknown | 388 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 87 | 22% |
Researcher | 68 | 17% |
Student > Bachelor | 47 | 12% |
Student > Master | 40 | 10% |
Student > Doctoral Student | 23 | 6% |
Other | 52 | 13% |
Unknown | 82 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 114 | 29% |
Agricultural and Biological Sciences | 83 | 21% |
Biochemistry, Genetics and Molecular Biology | 40 | 10% |
Medicine and Dentistry | 22 | 6% |
Chemistry | 10 | 3% |
Other | 33 | 8% |
Unknown | 97 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2023.
All research outputs
#1,835,516
of 25,371,288 outputs
Outputs from Molecular Neurodegeneration
#188
of 976 outputs
Outputs of similar age
#16,940
of 292,322 outputs
Outputs of similar age from Molecular Neurodegeneration
#1
of 12 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 976 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,322 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.