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Strategies to enhance the production of pinoresinol and its glucosides by endophytic fungus (Phomopsis sp. XP-8) isolated from Tu-chung bark

Overview of attention for article published in AMB Express, April 2018
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Title
Strategies to enhance the production of pinoresinol and its glucosides by endophytic fungus (Phomopsis sp. XP-8) isolated from Tu-chung bark
Published in
AMB Express, April 2018
DOI 10.1186/s13568-018-0584-5
Pubmed ID
Authors

Jing Zhu, Lu Yan, Xiaoguang Xu, Yan Zhang, Junling Shi, Chunmei Jiang, Dongyan Shao

Abstract

To improve the production yield of (+)-pinoresinol (Pin), (+)-pinoresinol monoglucoside (PMG), and (+)-pinoresinol diglucoside (PDG), different methods were conducted, including co-culture with resveratrol-producing Alternaria sp. MG1 spores and addition of Tu-chung in a medium at the start of cultivation, ultrasound treatment (40 kHZ, 10 min) on 5-day culture, and addition of ethanol and sodium butyrate on Day 3, followed by cultivation for an additional period of 2 days. At the end of the cultivation period (5 days), the liquid phase was collected for product analysis. Cells were collected for the determination of gene expression levels and then used in bioconversion using resting cells for another period of 2 days. The liquid phase was measured to determine the output of the target products and the expression levels of the key genes related to the biosynthesis of these compounds. Consequently, co-culture with Alternaria MG1 and addition of Tu-chung bark in the medium efficiently increased Pin, PMG, and PDG production yield in the biosynthesis systems using potato dextrose broth medium and resting cells of Phomopsis sp. XP-8. The key genes related to the biosynthesis of these compounds were significantly upregulated. However, in the majority of cases, the addition of ethanol and sodium butyrate, and ultrasound treatment decreased the production yield of Pin, PMG, and PDG. The change in production yield was not consistently accompanied by a change in gene expression.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 40%
Unspecified 3 20%
Student > Bachelor 3 20%
Researcher 1 7%
Unknown 2 13%
Readers by discipline Count As %
Unspecified 3 20%
Biochemistry, Genetics and Molecular Biology 3 20%
Agricultural and Biological Sciences 3 20%
Pharmacology, Toxicology and Pharmaceutical Science 2 13%
Environmental Science 1 7%
Other 1 7%
Unknown 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2018.
All research outputs
#11,386,549
of 12,808,036 outputs
Outputs from AMB Express
#752
of 804 outputs
Outputs of similar age
#195,008
of 224,372 outputs
Outputs of similar age from AMB Express
#32
of 32 outputs
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