Title |
Candidate genes for idiopathic epilepsy in four dog breeds
|
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Published in |
BMC Genomic Data, April 2011
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DOI | 10.1186/1471-2156-12-38 |
Pubmed ID | |
Authors |
Kari J Ekenstedt, Edward E Patterson, Katie M Minor, James R Mickelson |
Abstract |
Idiopathic epilepsy (IE) is a naturally occurring and significant seizure disorder affecting all dog breeds. Because dog breeds are genetically isolated populations, it is possible that IE is attributable to common founders and is genetically homogenous within breeds. In humans, a number of mutations, the majority of which are genes encoding ion channels, neurotransmitters, or their regulatory subunits, have been discovered to cause rare, specific types of IE. It was hypothesized that there are simple genetic bases for IE in some purebred dog breeds, specifically in Vizslas, English Springer Spaniels (ESS), Greater Swiss Mountain Dogs (GSMD), and Beagles, and that the gene(s) responsible may, in some cases, be the same as those already discovered in humans. |
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Geographical breakdown
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Spain | 1 | 1% |
Canada | 1 | 1% |
Unknown | 66 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 12% |
Other | 7 | 10% |
Student > Master | 6 | 9% |
Other | 14 | 20% |
Unknown | 15 | 22% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 17 | 25% |
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Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Environmental Science | 3 | 4% |
Other | 6 | 9% |
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