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Mathematical Modelling of the Sporulation-Initiation Network in Bacillus Subtilis Revealing the Dual Role of the Putative Quorum-Sensing Signal Molecule PhrA

Overview of attention for article published in Bulletin of Mathematical Biology, March 2010
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  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

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1 Wikipedia page

Citations

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19 Dimensions

Readers on

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59 Mendeley
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1 Connotea
Title
Mathematical Modelling of the Sporulation-Initiation Network in Bacillus Subtilis Revealing the Dual Role of the Putative Quorum-Sensing Signal Molecule PhrA
Published in
Bulletin of Mathematical Biology, March 2010
DOI 10.1007/s11538-010-9530-7
Pubmed ID
Authors

Sara Jabbari, John T. Heap, John R. King

Abstract

Bacillus subtilis cells may opt to forgo normal cell division and instead form spores if subjected to certain environmental stimuli, for example nutrient deficiency or extreme temperature. The resulting spores are extremely resilient and can survive for extensive periods of time, importantly under particularly harsh conditions such as those mentioned above. The sporulation process is highly time and energy consuming and essentially irreversible. The bacteria must therefore ensure that this route is only undertaken under appropriate circumstances. The gene regulation network governing sporulation initiation accordingly incorporates a variety of signals and is of significant complexity. We present a model of this network that includes four of these signals: nutrient levels, DNA damage, the products of the competence genes, and cell population size. Our results can be summarised as follows: (i) the model displays the correct phenotypic behaviour in response to these signals; (ii) a basal level of sda expression may prevent sporulation in the presence of nutrients; (iii) sporulation is more likely to occur in a large population of cells than in a small one; (iv) finally, and of most interest, PhrA can act simultaneously as a quorum-sensing signal and as a timing mechanism, delaying sporulation when the cell has damaged DNA, possibly thereby allowing the cell time to repair its DNA before forming a spore.

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Denmark 1 2%
United States 1 2%
Unknown 56 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 29%
Student > Ph. D. Student 12 20%
Student > Master 7 12%
Professor 6 10%
Unspecified 6 10%
Other 11 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 44%
Biochemistry, Genetics and Molecular Biology 8 14%
Mathematics 7 12%
Unspecified 7 12%
Engineering 3 5%
Other 8 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2013.
All research outputs
#3,496,445
of 12,213,589 outputs
Outputs from Bulletin of Mathematical Biology
#110
of 625 outputs
Outputs of similar age
#82,636
of 275,453 outputs
Outputs of similar age from Bulletin of Mathematical Biology
#1
of 8 outputs
Altmetric has tracked 12,213,589 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 625 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,453 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them