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miR-494-3p Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by PTEN/AKT Signaling in Human Glioblastoma Cells

Overview of attention for article published in Cellular & Molecular Neurobiology, February 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

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4 tweeters
patent
1 patent

Citations

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46 Dimensions

Readers on

mendeley
17 Mendeley
Title
miR-494-3p Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by PTEN/AKT Signaling in Human Glioblastoma Cells
Published in
Cellular & Molecular Neurobiology, February 2015
DOI 10.1007/s10571-015-0163-0
Pubmed ID
Authors

Xue-tao Li, Hang-zhou Wang, Zhi-wu Wu, Tian-quan Yang, Zhao-hui Zhao, Gui-lin Chen, Xue-shun Xie, Bin Li, Yong-xin Wei, Yu-lun Huang, You-xin Zhou, Zi-wei Du

Abstract

Malignant gliomas are the most common primary brain tumors, and the molecular mechanisms involving their progression and recurrence are still largely unclear. Substantial data indicate that the oncogene miR-494-3p is significantly elevated in gliomas, but the molecular functions of miR-494-3p in gliomagenesis are largely unknown. The present study aimed to explore the role of miR-494-3p and its molecular mechanism in human brain gliomas, malignant glioma cell lines, and cancer stem-like cells. The expression level of miR-494-3p in 48 human glioma issues and 8 normal brain tissues was determined using stem-loop real-time polymerase chain reaction (PCR). To study the function of miR-494-3p inhibitor in glioma cells, the miR-494-3p inhibitor lentivirus was used to transfect glioma cells. Transwell invasion system was used to estimate the effects of miR-494-3p inhibitor on the invasiveness of glioma cells. A mouse model was used to test the effect of miR-494-3p inhibitor on glioma proliferation and invasion in vivo. Results showed that the expression of miR-494-3p in human brain glioma tissues was higher than in normal brain tissues. Downregulated expression of miR-494-3p can inhibit the invasion and proliferation and promote apoptosis in glioma cells. Quantitative reverse transcription PCR and Western blotting analysis revealed that the expression of PTEN was increased after downexpression of miR-494-3p in glioma cells (U87 and U251). miR-494-3p inhibitor could prevent migration, invasion, proliferation, and promote apotosis in gliomas through PTEN/AKT pathway. Therefore, the study results have shown that miR-494-3p may act as a therapeutic target in gliomas.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 29%
Student > Master 4 24%
Student > Bachelor 3 18%
Student > Ph. D. Student 2 12%
Student > Postgraduate 1 6%
Other 2 12%
Readers by discipline Count As %
Medicine and Dentistry 6 35%
Agricultural and Biological Sciences 5 29%
Biochemistry, Genetics and Molecular Biology 3 18%
Immunology and Microbiology 1 6%
Chemistry 1 6%
Other 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2017.
All research outputs
#3,004,769
of 12,259,388 outputs
Outputs from Cellular & Molecular Neurobiology
#124
of 553 outputs
Outputs of similar age
#66,305
of 271,416 outputs
Outputs of similar age from Cellular & Molecular Neurobiology
#3
of 16 outputs
Altmetric has tracked 12,259,388 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 553 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,416 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.