Title |
T-box genes and the formation of vertebrate forelimb- and hindlimb specific pattern
|
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Published in |
Cell and Tissue Research, March 1999
|
DOI | 10.1007/s004410051266 |
Pubmed ID | |
Authors |
H.-G. Simon |
Abstract |
Limb patterning is thought to be a multistep process involving specification of the limb fields, establishment of defined signaling centers that globally inform cells of their position, interpretation of positional signals, and regulated growth and differentiation of the limb structures. Great progress has been made over the past few years in identifying the molecular players that control limb outgrowth and patterning, in particular, how the limb axes are specified. However, the molecular mechanism for determination of the morphological and functional differences between forelimbs and hindlimbs has remained elusive. The recent identification of a series of limb-specific transcription factors has now provided excellent candidates for such upstream regulators of limb identity, and has allowed new insights into the regulatory network of making a hand or a foot. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | 4% |
Canada | 1 | 4% |
Unknown | 23 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 24% |
Other | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Professor | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Other | 5 | 20% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 40% |
Biochemistry, Genetics and Molecular Biology | 9 | 36% |
Earth and Planetary Sciences | 1 | 4% |
Chemistry | 1 | 4% |
Unknown | 4 | 16% |