↓ Skip to main content

Cannabidiol Reverses Deficits in Hippocampal LTP in a Model of Alzheimer’s Disease

Overview of attention for article published in Neurochemical Research, March 2018
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#10 of 1,410)
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
1 news outlet
twitter
40 tweeters
facebook
4 Facebook pages
googleplus
1 Google+ user

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
45 Mendeley
Title
Cannabidiol Reverses Deficits in Hippocampal LTP in a Model of Alzheimer’s Disease
Published in
Neurochemical Research, March 2018
DOI 10.1007/s11064-018-2513-z
Pubmed ID
Authors

Blathnaid Hughes, Caroline E. Herron

Abstract

Here we demonstrate for the first time that cannabidiol (CBD) acts to protect synaptic plasticity in an in vitro model of Alzheimer's disease (AD). The non-psycho active component of Cannabis sativa, CBD has previously been shown to protect against the neurotoxic effects of beta amyloid peptide (Aβ) in cell culture and cognitive behavioural models of neurodegeneration. Hippocampal long-term potentiation (LTP) is an activity dependent increase in synaptic efficacy often used to study cellular mechanisms related to memory. Here we show that acute application of soluble oligomeric beta amyloid peptide (Aβ1-42) associated with AD, attenuates LTP in the CA1region of hippocampal slices from C57Bl/6 mice. Application of CBD alone did not alter LTP, however pre-treatment of slices with CBD rescued the Aβ1-42mediated deficit in LTP. We found that the neuroprotective effects of CBD were not reversed by WAY100635, ZM241385 or AM251, demonstrating a lack of involvement of 5HT1A, adenosine (A2A) or Cannabinoid type 1 (CB1) receptors respectively. However in the presence of the PPARγ antagonist GW9662 the neuroprotective effect of CBD was prevented. Our data suggests that this major component of Cannabis sativa, which lacks psychoactivity may have therapeutic potential for the treatment of AD.

Twitter Demographics

The data shown below were collected from the profiles of 40 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 10 22%
Student > Ph. D. Student 10 22%
Student > Bachelor 6 13%
Researcher 6 13%
Student > Master 4 9%
Other 9 20%
Readers by discipline Count As %
Unspecified 12 27%
Neuroscience 10 22%
Biochemistry, Genetics and Molecular Biology 5 11%
Agricultural and Biological Sciences 5 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Other 10 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 44. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2019.
All research outputs
#382,742
of 13,385,708 outputs
Outputs from Neurochemical Research
#10
of 1,410 outputs
Outputs of similar age
#16,163
of 270,913 outputs
Outputs of similar age from Neurochemical Research
#1
of 15 outputs
Altmetric has tracked 13,385,708 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,410 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,913 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.