Title |
Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer
|
---|---|
Published in |
Molecular Cancer, April 2011
|
DOI | 10.1186/1476-4598-10-40 |
Pubmed ID | |
Authors |
Francesco Crea, Elaine M Hurt, Lesley A Mathews, Stephanie M Cabarcas, Lei Sun, Victor E Marquez, Romano Danesi, William L Farrar |
Abstract |
Polycomb repressive complex 2 (PRC2) mediates gene silencing through histone H3K27 methylation. PRC2 components are over-expressed in metastatic prostate cancer (PC), and are required for cancer stem cell (CSC) self-renewal. 3-Dezaneplanocin-A (DZNeP) is an inhibitor of PRC2 with broad anticancer activity. |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Mexico | 1 | 1% |
United States | 1 | 1% |
Germany | 1 | 1% |
Unknown | 65 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 20% |
Researcher | 12 | 17% |
Student > Master | 8 | 12% |
Student > Bachelor | 6 | 9% |
Other | 5 | 7% |
Other | 11 | 16% |
Unknown | 13 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 36% |
Biochemistry, Genetics and Molecular Biology | 10 | 14% |
Medicine and Dentistry | 10 | 14% |
Chemistry | 3 | 4% |
Immunology and Microbiology | 2 | 3% |
Other | 3 | 4% |
Unknown | 16 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2023.
All research outputs
#3,272,274
of 22,788,370 outputs
Outputs from Molecular Cancer
#218
of 1,719 outputs
Outputs of similar age
#15,350
of 109,453 outputs
Outputs of similar age from Molecular Cancer
#1
of 12 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,719 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,453 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.