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Ketamine (s-ketamine) as fast-acting treatment for depression makes the news: https://t.co/B22oDRDSZC also, interesting paper on how it may not be just about NMDAr inhibition: https://t.co/TQCJebzV6Y (sadly paywalled). and s-ketamine in non-depressed folk:
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Ketamine actions include activation of the mTOR, deactivation of GSK-3 and eEF2, enhanced BDNF signaling, and activation of AMPARs https://t.co/n9pujBDAlF
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Convergent Mechanisms Underlying Rapid Antidepressant Action. https://t.co/M54Umb44bP