@wgibson @srikosuri Might this work with TDP-43 as the target? Cytoplasmic mislocalization seems important in ALS and some dementias (FTD). https://t.co/usQySVoqiO
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Want info on tdp43? It seems to cause trouble in almost all pALS. “97 % of patients display a common phenotype in disease-affected tissues, namely the deposition of the TAR-DNA binding protein (TDP)-43 [1, 2].” https://t.co/znXwAMyBFw
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TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets. https://t.co/WN77ybdHV1
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PubMed: TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets. http://t.co/33azxshgg5
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TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets. http://t.co/Pgtb5seayL