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Chemistry, physiological properties, and microbial production of hydroxycitric acid

Overview of attention for article published in Applied Microbiology & Biotechnology, May 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
1 news outlet
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
57 Mendeley
Title
Chemistry, physiological properties, and microbial production of hydroxycitric acid
Published in
Applied Microbiology & Biotechnology, May 2007
DOI 10.1007/s00253-007-0962-4
Pubmed ID
Authors

Takashi Yamada, Hiroyuki Hida, Yasuhiro Yamada

Abstract

The tropical plants Garcinia cambogia and Hibiscus subdariffa produce hydroxycitric acid (HCA), of which the absolute configurations are (2S,3S) and (2S,3R), respectively. (2S,3S)-HCA is an inhibitor of ATP-citrate lyase, which is involved in fatty acid synthesis. (2S,3R)-HCA inhibits pancreatic alpha-amylase and intestinal alpha-glucosidase, leading to a reduction in carbohydrate metabolism. In this study, we review current knowledge on the structure, biological occurrence, and physiological properties of HCA. The availability of HCA is limited by the restricted habitat of its source plants and the difficulty of stereoselective organic synthesis. Hence, in our recent study, thousands of microbial strains were screened and finally two bacterial strains were, for the first time, found to produce trace amounts of HCA. The HCA variants produced were the Hibiscus-type (2S,3R) enantiomer. Subsequent genome shuffling rapidly generated a mutant population with improved HCA yield relative to the parent strain of bacteria. These bacteria are a potential alternative source of natural HCA.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
Australia 1 2%
Malaysia 1 2%
Brazil 1 2%
United States 1 2%
Sweden 1 2%
Unknown 51 89%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 18%
Researcher 10 18%
Student > Ph. D. Student 10 18%
Student > Bachelor 6 11%
Student > Postgraduate 5 9%
Other 16 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 32%
Chemistry 8 14%
Medicine and Dentistry 7 12%
Unspecified 6 11%
Biochemistry, Genetics and Molecular Biology 5 9%
Other 13 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2018.
All research outputs
#1,078,736
of 12,926,183 outputs
Outputs from Applied Microbiology & Biotechnology
#80
of 5,377 outputs
Outputs of similar age
#26,574
of 275,097 outputs
Outputs of similar age from Applied Microbiology & Biotechnology
#2
of 126 outputs
Altmetric has tracked 12,926,183 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,377 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,097 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.