Title |
Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum
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Published in |
Archives of Pharmacal Research, July 2011
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DOI | 10.1007/s12272-011-0614-1 |
Pubmed ID | |
Authors |
Myung-Hoe Kim, Agung Nugroho, Jongwon Choi, Jong Hee Park, Hee-Juhn Park |
Abstract |
To identify an analgesic/anti-inflammatory component from the leaves of Rhododendron aureum (Ericaceae), phytochemical isolation and pharmacological assays (writhing assays and vascular permeability assay for analgesic action in mice; carrageenan-induced paw edemaand TPA-induced ear edema assays of anti-inflammatory action in rats) were performed. Four compounds were isolated from the active fraction (BuOH fraction) by silica gel column chromatography and identified as (-)-rhododendrol, (-)-rhododendrin, avicularin and hyperoside by spectroscopic methods. Rhododendrin, the main compound of the BuOH fraction, exhibited significant analgesic actions in mice and anti-inflammatory actions in rats. This compound accounted for 3.1% of the MeOH extract and 0.48% of dried leaves, respectively, on HPLC analysis. These results suggest that rhododendrin is the major biologically active substance in the leaves of R. aureum with analgesic/anti-inflammatory activity. |
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Geographical breakdown
Country | Count | As % |
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Korea, Republic of | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 19% |
Student > Ph. D. Student | 5 | 19% |
Professor > Associate Professor | 3 | 12% |
Other | 2 | 8% |
Student > Master | 2 | 8% |
Other | 4 | 15% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
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Pharmacology, Toxicology and Pharmaceutical Science | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Environmental Science | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Other | 3 | 12% |
Unknown | 9 | 35% |