Title |
Protein myristoylation in health and disease
|
---|---|
Published in |
Journal of Chemical Biology, November 2009
|
DOI | 10.1007/s12154-009-0032-8 |
Pubmed ID | |
Authors |
Megan H. Wright, William P. Heal, David J. Mann, Edward W. Tate |
Abstract |
N-myristoylation is the attachment of a 14-carbon fatty acid, myristate, onto the N-terminal glycine residue of target proteins, catalysed by N-myristoyltransferase (NMT), a ubiquitous and essential enzyme in eukaryotes. Many of the target proteins of NMT are crucial components of signalling pathways, and myristoylation typically promotes membrane binding that is essential for proper protein localisation or biological function. NMT is a validated therapeutic target in opportunistic infections of humans by fungi or parasitic protozoa. Additionally, NMT is implicated in carcinogenesis, particularly colon cancer, where there is evidence for its upregulation in the early stages of tumour formation. However, the study of myristoylation in all organisms has until recently been hindered by a lack of techniques for detection and identification of myristoylated proteins. Here we introduce the chemistry and biology of N-myristoylation and NMT, and discuss new developments in chemical proteomic technologies that are meeting the challenge of studying this important co-translational modification in living systems. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Germany | 1 | <1% |
Norway | 1 | <1% |
Israel | 1 | <1% |
Slovakia | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 241 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 59 | 24% |
Student > Bachelor | 35 | 14% |
Student > Master | 34 | 14% |
Researcher | 31 | 13% |
Student > Doctoral Student | 9 | 4% |
Other | 32 | 13% |
Unknown | 47 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 69 | 28% |
Biochemistry, Genetics and Molecular Biology | 55 | 22% |
Chemistry | 34 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 5% |
Medicine and Dentistry | 7 | 3% |
Other | 17 | 7% |
Unknown | 53 | 21% |