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Sustained exenatide delivery via intracapsular microspheres for improved survival and function of microencapsulated porcine islets

Overview of attention for article published in Drug Delivery and Translational Research, January 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 156)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
9 news outlets
blogs
2 blogs
twitter
1 tweeter
facebook
1 Facebook page

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
9 Mendeley
Title
Sustained exenatide delivery via intracapsular microspheres for improved survival and function of microencapsulated porcine islets
Published in
Drug Delivery and Translational Research, January 2018
DOI 10.1007/s13346-018-0484-x
Pubmed ID
Authors

Benjamin Lew, In-Yong Kim, Hyungsoo Choi, Kyekyoon Kim

Abstract

The ability of glucagon-like peptide-1 analogs to enhance glucose-dependent insulin secretion and to inhibit β cell apoptosis could be of potential benefit for islet transplantation. In this study, we investigated the effect of sustained local delivery of exenatide, a synthetic exendin-4, on the in vitro viability and function of encapsulated porcine islets. Prior to encapsulation, we fabricated exenatide-loaded poly(latic-co-glycolic acid) microspheres, and investigated their release behavior with different initial drug-loading amounts. Exenatide-loaded microspheres, exhibiting a sustained release over 21 days, were subsequently chosen and co-encapsulated with porcine islets in alginate microcapsules. During the 21-day period, the islets co-encapsulated with the exenatide-loaded microspheres exhibited improved survival and glucose-stimulated insulin secretion, compared to those without. This suggested that the intracapsular sustained delivery of exenatide via microspheres could be a promising strategy for improving survival and function of microencapsulated porcine islets for islet xenotransplantation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 44%
Student > Bachelor 2 22%
Other 1 11%
Researcher 1 11%
Student > Doctoral Student 1 11%
Other 0 0%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 3 33%
Medicine and Dentistry 3 33%
Agricultural and Biological Sciences 1 11%
Unspecified 1 11%
Engineering 1 11%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 76. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2018.
All research outputs
#201,254
of 12,886,764 outputs
Outputs from Drug Delivery and Translational Research
#2
of 156 outputs
Outputs of similar age
#10,190
of 346,743 outputs
Outputs of similar age from Drug Delivery and Translational Research
#1
of 5 outputs
Altmetric has tracked 12,886,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 156 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,743 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them