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Nucleoside-Lipid-Based Nanocarriers for Sorafenib Delivery

Overview of attention for article published in Nanoscale Research Letters, January 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

Mentioned by

patent
1 patent

Citations

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28 Dimensions

Readers on

mendeley
33 Mendeley
Title
Nucleoside-Lipid-Based Nanocarriers for Sorafenib Delivery
Published in
Nanoscale Research Letters, January 2018
DOI 10.1186/s11671-017-2420-2
Pubmed ID
Authors

Sebastien Benizri, Ludivine Ferey, Bruno Alies, Naila Mebarek, Gaelle Vacher, Ananda Appavoo, Cathy Staedel, Karen Gaudin, Philippe Barthélémy

Abstract

Although the application of sorafenib, a small inhibitor of tyrosine protein kinases, to cancer treatments remains a worldwide option in chemotherapy, novel strategies are needed to address the low water solubility (< 5 μM), toxicity, and side effects issues of this drug. In this context, the use of nanocarriers is currently investigated in order to overcome these drawbacks. In this contribution, we report a new type of sorafenib-based nanoparticles stabilized by hybrid nucleoside-lipids. The solid lipid nanoparticles (SLNs) showed negative or positive zeta potential values depending on the nucleoside-lipid charge. Transmission electron microscopy of sorafenib-loaded SLNs revealed parallelepiped nanoparticles of about 200 nm. Biological studies achieved on four different cell lines, including liver and breast cancers, revealed enhanced anticancer activities of Sorafenib-based SLNs compared to the free drug. Importantly, contrast phase microscopy images recorded after incubation of cancer cells in the presence of SLNs at high concentration in sorafenib (> 80 μM) revealed a total cancer cell death in all cases. These results highlight the potential of nucleoside-lipid-based SLNs as drug delivery systems.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 21%
Student > Master 5 15%
Researcher 3 9%
Professor 3 9%
Professor > Associate Professor 2 6%
Other 3 9%
Unknown 10 30%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 8 24%
Chemistry 6 18%
Biochemistry, Genetics and Molecular Biology 4 12%
Environmental Science 2 6%
Earth and Planetary Sciences 1 3%
Other 2 6%
Unknown 10 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2022.
All research outputs
#7,435,148
of 22,729,647 outputs
Outputs from Nanoscale Research Letters
#207
of 1,076 outputs
Outputs of similar age
#153,670
of 441,671 outputs
Outputs of similar age from Nanoscale Research Letters
#4
of 17 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,076 research outputs from this source. They receive a mean Attention Score of 3.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,671 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.