↓ Skip to main content

Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme

Overview of attention for article published in Journal of Neuro-Oncology, June 2006
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

patent
8 patents

Citations

dimensions_citation
376 Dimensions

Readers on

mendeley
255 Mendeley
Title
Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme
Published in
Journal of Neuro-Oncology, June 2006
DOI 10.1007/s11060-006-9195-0
Pubmed ID
Authors

Klaus Maier-Hauff, Ronny Rothe, Regina Scholz, Uwe Gneveckow, Peter Wust, Burghard Thiesen, Annelie Feussner, Andreas von Deimling, Norbert Waldoefner, Roland Felix, Andreas Jordan

Abstract

We aimed to evaluate the feasibility and tolerability of the newly developed thermotherapy using magnetic nanoparticles on recurrent glioblastoma multiforme. Fourteen patients received 3-dimensional image guided intratumoral injection of aminosilane coated iron oxide nanoparticles. The patients were then exposed to an alternating magnetic field to induce particle heating. The amount of fluid and the spatial distribution of the depots were planned in advance by means of a specially developed treatment planning software following magnetic resonance imaging (MRI). The actually achieved magnetic fluid distribution was measured by computed tomography (CT), which after matching to pre-operative MRI data enables the calculation of the expected heat distribution within the tumor in dependence of the magnetic field strength. Patients received 4-10 (median: 6) thermotherapy treatments following instillation of 0.1-0.7 ml (median: 0.2) of magnetic fluid per ml tumor volume and single fractions (2 Gy) of a radiotherapy series of 16-70 Gy (median: 30). Thermotherapy using magnetic nanoparticles was tolerated well by all patients with minor or no side effects. Median maximum intratumoral temperatures of 44.6 degrees C (42.4-49.5 degrees C) were measured and signs of local tumor control were observed. In conclusion, deep cranial thermotherapy using magnetic nanoparticles can be safely applied on glioblastoma multiforme patients.

Mendeley readers

The data shown below were compiled from readership statistics for 255 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 3 1%
India 2 <1%
Germany 2 <1%
United States 2 <1%
Brazil 1 <1%
Malaysia 1 <1%
Romania 1 <1%
Austria 1 <1%
Canada 1 <1%
Other 1 <1%
Unknown 240 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 75 29%
Researcher 43 17%
Student > Master 40 16%
Student > Doctoral Student 20 8%
Unspecified 17 7%
Other 60 24%
Readers by discipline Count As %
Medicine and Dentistry 44 17%
Chemistry 36 14%
Physics and Astronomy 35 14%
Engineering 31 12%
Materials Science 28 11%
Other 81 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2018.
All research outputs
#2,302,038
of 12,902,491 outputs
Outputs from Journal of Neuro-Oncology
#168
of 1,932 outputs
Outputs of similar age
#52,489
of 275,474 outputs
Outputs of similar age from Journal of Neuro-Oncology
#2
of 58 outputs
Altmetric has tracked 12,902,491 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,932 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,474 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.