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Blocking of Striated Muscle Degeneration by Serotonin in C. elegans

Overview of attention for article published in Journal of Muscle Research and Cell Motility, June 2006
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About this Attention Score

  • Among the highest-scoring outputs from this source (#27 of 188)
  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

patent
2 patents

Citations

dimensions_citation
23 Dimensions

Readers on

mendeley
25 Mendeley
Title
Blocking of Striated Muscle Degeneration by Serotonin in C. elegans
Published in
Journal of Muscle Research and Cell Motility, June 2006
DOI 10.1007/s10974-006-9070-9
Pubmed ID
Authors

Maité Carre-Pierrat, Marie-Christine Mariol, Lucie Chambonnier, Aurélie Laugraud, Fabienne Heskia, Jean Giacomotto, Laurent Ségalat

Abstract

Prevention of muscle fiber degeneration is a key issue in the treatment of muscular dystrophies such as Duchenne Muscular Dystrophy (DMD). It is widely postulated that existing pharmaceutical compounds might potentially be beneficial to DMD patients, but tools to identify them are lacking. Here, by using a Caenorhabditis elegans model of dystrophin-dependent muscular dystrophy, we show that the neurohormone serotonin and some of its agonists are potent suppressors of muscle degeneration. Inhibitors of serotonin reuptake transporters, which prolong the action of endogenous serotonin, have a similar effect. Moreover, reduction of serotonin levels leads to degeneration of non-dystrophic muscles. Our results demonstrate that serotonin is critical to C. elegans striated muscles. These findings reveal a new function of serotonin in striated muscles.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 36%
Student > Ph. D. Student 6 24%
Student > Master 3 12%
Other 2 8%
Student > Bachelor 2 8%
Other 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 48%
Biochemistry, Genetics and Molecular Biology 5 20%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Unspecified 2 8%
Chemical Engineering 1 4%
Other 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2015.
All research outputs
#3,547,606
of 12,343,108 outputs
Outputs from Journal of Muscle Research and Cell Motility
#27
of 188 outputs
Outputs of similar age
#78,853
of 266,560 outputs
Outputs of similar age from Journal of Muscle Research and Cell Motility
#1
of 5 outputs
Altmetric has tracked 12,343,108 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 188 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,560 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them