Title |
Comprehensive lung injury pathology induced by mTOR inhibitors
|
---|---|
Published in |
Clinical and Translational Oncology, August 2009
|
DOI | 10.1007/s12094-009-0394-y |
Pubmed ID | |
Authors |
Guadalupe Aparicio, Moisés B. Calvo, Vanessa Medina, Ovidio Fernández, Paula Jiménez, Martina Lema, Angélica Figueroa, Luis M. Antón Aparicio |
Abstract |
Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation and migration, and loss of alveolar gas exchange units. Previous studies of pulmonary fibrosis have mainly focused on the fibroproliferative process in the lungs. However, the molecular mechanism by which sirolimus promotes lung fibrosis remains elusive. Here, we propose an overall cascade hypothesis of interstitial lung diseases that represents a common, partly underlying synergism among them as well as the lung pathogenesis side effects of mammalian target of rapamycin inhibitors. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 5% |
Germany | 1 | 5% |
Unknown | 17 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 26% |
Student > Ph. D. Student | 4 | 21% |
Student > Bachelor | 3 | 16% |
Other | 2 | 11% |
Professor | 1 | 5% |
Other | 2 | 11% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 37% |
Agricultural and Biological Sciences | 5 | 26% |
Biochemistry, Genetics and Molecular Biology | 3 | 16% |
Chemistry | 1 | 5% |
Unknown | 3 | 16% |