| Title |
Extremely high expression of serum alpha-fetoprotein level of gastric adenocarcinoma: a rare case with an unexpected well-prognosis
|
|---|---|
| Published in |
SpringerPlus, December 2016
|
| DOI | 10.1186/s40064-016-3719-7 |
| Pubmed ID | |
| Authors |
Weihua Gong, Dawei Shou, Ping Gong |
| Abstract |
Alpha-fetoprotein (AFP)-producing gastric cancer is a relatively rare form of stomach malignancy. Patients with higher serum AFP level (>300 ng/mL) will have a poorer prognosis. In this study, we present a case of 77-year-old woman with an extremely high expression of serum AFP level (>10,000 ng/mL) of gastric cancer. Histological examination revealed gastric adenocarcinoma (Bormann III gastric tumor) invading into the serosal layer and vessel. After receiving a successful total gastrectomy with D2 dissection, this patient underwent chemotherapy with SOX [oxaliplatin (130 mg/m(2)/day) iv. at day 1 + S-1 (80 mg/m(2)/day) from day 1-day 14]. The patient remains alive without disease for 29 months after surgery. Serum AFP level decreased to normal range. We have evaluated the level of AFP, and discussed the reason for the good prognosis for this patient. The good prognosis may be related with her early stage (N0 and without liver metastasis) and radical surgery. |
Mendeley readers
The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 1 | 33% |
| Other | 1 | 33% |
| Student > Master | 1 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 33% |
| Design | 1 | 33% |
| Unknown | 1 | 33% |