Title |
Tuberculosis in infants: a retrospective study in China
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Published in |
SpringerPlus, April 2016
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DOI | 10.1186/s40064-016-2184-7 |
Pubmed ID | |
Authors |
Ruo-Lin Li, Jun-Li Wang, Xin-Feng Wang, Mao-Shui Wang |
Abstract |
To describe the demographics, clinical characteristics and microbiologic findings of infant (≤2 years old) tuberculosis (TB) in a high TB burden country. Between Feb, 2007 and Jun, 2015, 115 TB infants who admitted to our hospital were enrolled in the study. Their clinicopathological characteristics were reviewed and analyzed. The mean age was 10.1 ± 7.4 (SD) months, and 84 of 115 infants (73.0 %) were males. 23 patients (20.0 %) had isolated pulmonary TB, 18 patients (15.7 %) had pulmonary and extrapulmonary TB (EPTB), the remaining 74 patients (64.4 %) had exclusively EPTB. The most common site of EPTB was lymph node (n = 61), 54 cases were left axillary lymph node involvement. 49 of 51 patients (96.1 %) were validated by pathological examination, 5 of 57 patients (8.8 %) were positive on acid fast bacilli smear, and 27 of 103 patients (26.2 %) were confirmed by mycobacterial culture. 29 of 59 patients (49.2 %) were PPD positive, 14 of 30 patients (46.7 %) were T-SPOT.TB positive. The most common complaints of patients were lymph node swelling (53.0 %), fever (36.5 %), cough (28.7 %) and dyspnea (10.4 %). There was significant difference in the time before hospital admission among different types of tuberculosis (P < 0.01), fever was also a factor influencing the time (P < 0.05). In infants, the sensitivities of routine TB tests were low and emphasize the need for improved diagnostics; EPTB was more common than pulmonary TB, tuberculous lymphadenitis constituted a high proportion of EPTB; there appears to be an association between the incidence of axillary lymph node TB and BCG vaccination among infants in China. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 16% |
Student > Bachelor | 4 | 16% |
Researcher | 3 | 12% |
Other | 2 | 8% |
Professor | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 36% |
Nursing and Health Professions | 2 | 8% |
Agricultural and Biological Sciences | 1 | 4% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Social Sciences | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 40% |