| Title |
Insular Cortex is Critical for the Perception, Modulation, and Chronification of Pain
|
|---|---|
| Published in |
Neuroscience Bulletin, February 2016
|
| DOI | 10.1007/s12264-016-0016-y |
| Pubmed ID | |
| Authors |
Changbo Lu, Tao Yang, Huan Zhao, Ming Zhang, Fancheng Meng, Hao Fu, Yingli Xie, Hui Xu |
| Abstract |
An increasing body of neuroimaging and electrophysiological studies of the brain suggest that the insular cortex (IC) integrates multimodal salient information ranging from sensation to cognitive-affective events to create conscious interoception. Especially with regard to pain experience, the IC has been supposed to participate in both sensory-discriminative and affective-motivational aspects of pain. In this review, we discuss the latest data proposing that subregions of the IC are involved in isolated pain networks: the posterior sensory circuit and the anterior emotional network. Due to abundant connections with other brain areas, the IC is likely to serve as an interface where cross-modal shaping of pain occurs. In chronic pain, however, this mode of emotional awareness and the modulation of pain are disrupted. We highlight some of the molecular mechanisms underlying the changes of the pain modulation system that contribute to the transition from acute to chronic pain in the IC. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| Canada | 1 | 20% |
| Netherlands | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 40% |
| Members of the public | 2 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 274 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | <1% |
| Italy | 1 | <1% |
| France | 1 | <1% |
| Unknown | 271 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 46 | 17% |
| Researcher | 42 | 15% |
| Student > Ph. D. Student | 42 | 15% |
| Student > Bachelor | 25 | 9% |
| Student > Doctoral Student | 19 | 7% |
| Other | 38 | 14% |
| Unknown | 62 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 77 | 28% |
| Medicine and Dentistry | 37 | 14% |
| Psychology | 25 | 9% |
| Agricultural and Biological Sciences | 13 | 5% |
| Nursing and Health Professions | 11 | 4% |
| Other | 32 | 12% |
| Unknown | 79 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2022.
All research outputs
#1,464,110
of 25,601,426 outputs
Outputs from Neuroscience Bulletin
#17
of 930 outputs
Outputs of similar age
#23,733
of 313,480 outputs
Outputs of similar age from Neuroscience Bulletin
#3
of 16 outputs
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