| Title |
A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines
|
|---|---|
| Published in |
Sports Medicine - Open, January 2018
|
| DOI | 10.1186/s40798-017-0114-z |
| Pubmed ID | |
| Authors |
Fatima Al-Khelaifi, Ilhame Diboun, Francesco Donati, Francesco Botrè, Mohammed Alsayrafi, Costas Georgakopoulos, Karsten Suhre, Noha A. Yousri, Mohamed A. Elrayess |
| Abstract |
The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite athletes and to identify the potential metabolic pathways underlying these differences. Metabolic profiling of serum samples from 191 elite athletes from different sports disciplines (121 high- and 70 moderate-endurance athletes, including 44 high- and 144 moderate-power athletes), who participated in national or international sports events and tested negative for doping abuse at anti-doping laboratories, was performed using non-targeted metabolomics-based mass spectroscopy combined with ultrahigh-performance liquid chromatography. Multivariate analysis was conducted using orthogonal partial least squares discriminant analysis. Differences in metabolic levels between high- and moderate-power and endurance sports were assessed by univariate linear models. Out of 743 analyzed metabolites, gamma-glutamyl amino acids were significantly reduced in both high-power and high-endurance athletes compared to moderate counterparts, indicating active glutathione cycle. High-endurance athletes exhibited significant increases in the levels of several sex hormone steroids involved in testosterone and progesterone synthesis, but decreases in diacylglycerols and ecosanoids. High-power athletes had increased levels of phospholipids and xanthine metabolites compared to moderate-power counterparts. This pilot data provides evidence that high-power and high-endurance athletes exhibit a distinct metabolic profile that reflects steroid biosynthesis, fatty acid metabolism, oxidative stress, and energy-related metabolites. Replication studies are warranted to confirm differences in the metabolic profiles associated with athletes' elite performance in independent data sets, aiming ultimately for deeper understanding of the underlying biochemical processes that could be utilized as biomarkers with potential therapeutic implications. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 33% |
| Australia | 1 | 8% |
| France | 1 | 8% |
| Italy | 1 | 8% |
| United Kingdom | 1 | 8% |
| Qatar | 1 | 8% |
| Unknown | 3 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 50% |
| Scientists | 6 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 143 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 15% |
| Student > Ph. D. Student | 21 | 15% |
| Student > Master | 14 | 10% |
| Student > Bachelor | 12 | 8% |
| Other | 8 | 6% |
| Other | 28 | 20% |
| Unknown | 38 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 21 | 15% |
| Biochemistry, Genetics and Molecular Biology | 17 | 12% |
| Agricultural and Biological Sciences | 12 | 8% |
| Medicine and Dentistry | 11 | 8% |
| Nursing and Health Professions | 8 | 6% |
| Other | 27 | 19% |
| Unknown | 47 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2019.
All research outputs
#4,316,936
of 23,577,761 outputs
Outputs from Sports Medicine - Open
#266
of 490 outputs
Outputs of similar age
#92,820
of 444,699 outputs
Outputs of similar age from Sports Medicine - Open
#7
of 13 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 490 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.3. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.