Title |
Chemotherapy-Induced Cardiotoxicity
|
---|---|
Published in |
Current Heart Failure Reports, March 2012
|
DOI | 10.1007/s11897-012-0083-y |
Pubmed ID | |
Authors |
Amir Y. Shaikh, Jeffrey A. Shih |
Abstract |
Anthracycline-based chemotherapeutics have long been recognized as effective agents for treating a wide range of malignancies. However, their use is not without significant adverse cardiotoxic side effects. Strategies for prevention involve limiting free-radical production and subsequent cardiac myocyte damage. Dexrazoxane remains the most widely studied cardioprotective medication. Alternative agents may reduce cardiotoxicity but may still cause significant cardiovascular problems. The role of β-blockers and angiotensin-converting enzyme inhibitors in the treatment of heart failure is well proven. The role of these medications in the prevention and treatment of chemotherapy-induced cardiotoxicity is not well established. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | <1% |
Germany | 1 | <1% |
Chile | 1 | <1% |
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Unknown | 410 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 72 | 17% |
Student > Master | 61 | 15% |
Researcher | 38 | 9% |
Student > Ph. D. Student | 37 | 9% |
Student > Postgraduate | 35 | 8% |
Other | 74 | 18% |
Unknown | 98 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 149 | 36% |
Biochemistry, Genetics and Molecular Biology | 36 | 9% |
Agricultural and Biological Sciences | 32 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 32 | 8% |
Nursing and Health Professions | 12 | 3% |
Other | 43 | 10% |
Unknown | 111 | 27% |