↓ Skip to main content

Pharmacokinetic Determinants of Drug Abuse and Dependence

Overview of attention for article published in Clinical Pharmacokinetics, January 1986
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

policy
1 policy source
wikipedia
1 Wikipedia page

Citations

dimensions_citation
75 Dimensions

Readers on

mendeley
14 Mendeley
Title
Pharmacokinetic Determinants of Drug Abuse and Dependence
Published in
Clinical Pharmacokinetics, January 1986
DOI 10.2165/00003088-198611020-00004
Pubmed ID
Authors

U Busto, E M Sellers

Abstract

Drugs that produce physical dependence or have similar pharmacological profiles to highly abused drugs are unlikely to be considered acceptable for marketing. Thus, the prediction of abuse and dependence becomes an important issue in the development of new psychotropic drugs. Both pharmacokinetic and non-pharmacokinetic factors play an important role in predicting dependence and abuse liability of drugs. Evidence for the importance of pharmacological factors includes: the demonstration of drug binding to receptors of abused drugs; tolerance; ability to maintain self-administration; and spontaneous or antagonist precipitated withdrawal. The pharmacokinetic properties that presumably contribute to persistent self-administration and abuse include rapid delivery of drug to the central nervous system (CNS), rapid absorption, low protein binding and high free drug clearance. The pharmacokinetic properties of a drug associated with dependence will include long half-life, low free drug clearance and presence of the drug in the body at high enough concentrations and for sufficient time to permit tolerance to develop. These properties have important clinical implications for treatment and research in the area of abuse and dependence liability of psychoactive drugs.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Professor 3 21%
Student > Bachelor 2 14%
Student > Doctoral Student 2 14%
Student > Master 2 14%
Student > Postgraduate 1 7%
Other 4 29%
Readers by discipline Count As %
Medicine and Dentistry 5 36%
Unspecified 2 14%
Biochemistry, Genetics and Molecular Biology 2 14%
Psychology 2 14%
Agricultural and Biological Sciences 1 7%
Other 2 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2011.
All research outputs
#1,320,834
of 8,111,249 outputs
Outputs from Clinical Pharmacokinetics
#73
of 659 outputs
Outputs of similar age
#46,277
of 239,945 outputs
Outputs of similar age from Clinical Pharmacokinetics
#2
of 14 outputs
Altmetric has tracked 8,111,249 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 659 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,945 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.