Title |
Phagocytosis of Microglia in the Central Nervous System Diseases
|
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Published in |
Molecular Neurobiology, January 2014
|
DOI | 10.1007/s12035-013-8620-6 |
Pubmed ID | |
Authors |
Ruying Fu, Qingyu Shen, Pengfei Xu, Jin Jun Luo, Yamei Tang |
Abstract |
Microglia, the resident macrophages of the central nervous system, rapidly activate in nearly all kinds of neurological diseases. These activated microglia become highly motile, secreting inflammatory cytokines, migrating to the lesion area, and phagocytosing cell debris or damaged neurons. During the past decades, the secretory property and chemotaxis of microglia have been well-studied, while relatively less attention has been paid to microglial phagocytosis. So far there is no obvious concordance with whether it is beneficial or detrimental in tissue repair. This review focuses on phagocytic phenotype of microglia in neurological diseases such as Alzheimer's disease, multiple sclerosis, Parkinson's disease, traumatic brain injury, ischemic and other brain diseases. Microglial morphological characteristics, involved receptors and signaling pathways, distribution variation along with time and space changes, and environmental factors that affecting phagocytic function in each disease are reviewed. Moreover, a comparison of contributions between macrophages from peripheral circulation and the resident microglia to these pathogenic processes will also be discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | <1% |
United Kingdom | 2 | <1% |
Portugal | 1 | <1% |
Brazil | 1 | <1% |
Czechia | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 718 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 181 | 25% |
Student > Bachelor | 105 | 14% |
Student > Master | 99 | 14% |
Researcher | 83 | 11% |
Student > Doctoral Student | 34 | 5% |
Other | 71 | 10% |
Unknown | 155 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 154 | 21% |
Agricultural and Biological Sciences | 123 | 17% |
Biochemistry, Genetics and Molecular Biology | 106 | 15% |
Medicine and Dentistry | 55 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 26 | 4% |
Other | 86 | 12% |
Unknown | 178 | 24% |