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Temporal dynamics of the very premature infant gut dominant microbiota

Overview of attention for article published in BMC Microbiology, December 2014
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  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

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9 tweeters
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1 Google+ user

Citations

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79 Mendeley
Title
Temporal dynamics of the very premature infant gut dominant microbiota
Published in
BMC Microbiology, December 2014
DOI 10.1186/s12866-014-0325-0
Pubmed ID
Authors

Fabien Aujoulat, Laurent Roudière, Jean-Charles Picaud, Aurélien Jacquot, Anne Filleron, Dorine Neveu, Thierry-Pascal Baum, Hélène Marchandin, Estelle Jumas-Bilak

Abstract

BackgroundThe very-preterm infant gut microbiota is increasingly explored due to its probable role in the development of life threatening diseases. Results of high-throughput studies validate and renew the interest in approaches with lower resolution such as PCR-Temporal Temperature Gel Electrophoresis (TTGE) for the follow-up of dominant microbiota dynamics. We report here an extensive longitudinal study of gut colonization in very preterm infants. We explored by 16S rDNA-based PCR-TTGE a total of 354 stool specimens sampled during routine monitoring from the 1st to the 8th week of life in 30 very pre-term infants born before 30 weeks of gestational age.ResultsCombining comparison with a diversity ladder and sequencing allowed affiliation of 50 Species-Level Operational Taxonomic Units (SLOTUs) as well as semi-quantitative estimation of Operational Taxonomic Units (OTUs). Coagulase-negative staphylococci, mainly the Staphylococcus epidermidis, was found in all the infants during the study period and was the most represented (75.7% of the SLOTUs) from the first days of life. Enterococci, present in 60% of the infants were early, highly represented and persistent colonizers of the premature gut. Later Enterobacteriaceae and the genus Clostridium appeared and were found in 10 (33%) and 21 infants (70%), respectively. We showed a high representation of Veillonella in more than a quarter of the infants and being able to persistently colonize premature gut. The genera Anaerococcus, Aquabacterium, Bacillus, Bifidobacterium, Corynebacterium, Micrococcus, Oceanobacillus, Propionibacterium, Pseudomonas, Rothia, Sarcina, Sneathia and Streptococcus were observed as transient or persistent colonizers, each genus being found in a minority of infants.ConclusionsDespite low resolution, PCR-TTGE remains complementary to high-throughput sequencing-based approaches because it allows the follow-up of dominant bacteria in gut microbiota in a large longitudinal cohorts of preterm neonates. We described the development of pre-term gut microbiota that should be now replaced regarding the functional role of major OTUs.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
United Kingdom 1 1%
Croatia 1 1%
Japan 1 1%
Spain 1 1%
Unknown 73 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 22%
Researcher 14 18%
Student > Master 14 18%
Student > Bachelor 14 18%
Unspecified 6 8%
Other 14 18%
Readers by discipline Count As %
Medicine and Dentistry 23 29%
Agricultural and Biological Sciences 22 28%
Unspecified 12 15%
Biochemistry, Genetics and Molecular Biology 7 9%
Immunology and Microbiology 5 6%
Other 10 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2016.
All research outputs
#3,404,158
of 13,626,890 outputs
Outputs from BMC Microbiology
#382
of 2,034 outputs
Outputs of similar age
#66,311
of 294,497 outputs
Outputs of similar age from BMC Microbiology
#17
of 137 outputs
Altmetric has tracked 13,626,890 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 2,034 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,497 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.