Title |
Lithium for prevention of mood episodes in bipolar disorders: systematic review and meta-analysis
|
---|---|
Published in |
International Journal of Bipolar Disorders, December 2014
|
DOI | 10.1186/s40345-014-0015-8 |
Pubmed ID | |
Authors |
Emanuel Severus, Matthew J Taylor, Cathrin Sauer, Andrea Pfennig, Philipp Ritter, Michael Bauer, John R Geddes |
Abstract |
In a previous meta-analysis of randomized controlled trials comparing lithium with placebo as a long-term treatment in bipolar disorders, we observed a clear preventative effect for manic episodes; however, the effect was equivocal for depressive episodes. Since then, the evidence base has grown further. In this update, we furthermore present the data on efficacy of lithium in comparison to alternative drug treatments. In addition, we analyze the data comparing lithium with placebo and other treatments regarding drop-outs due to reasons other than a mood episode and completion of study (no mood episode and no drop-out to reasons other than a mood episode). |
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Canada | 2 | 12% |
United States | 2 | 12% |
Greece | 1 | 6% |
Austria | 1 | 6% |
Unknown | 7 | 41% |
Demographic breakdown
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Members of the public | 9 | 53% |
Practitioners (doctors, other healthcare professionals) | 7 | 41% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | <1% |
Sweden | 1 | <1% |
Romania | 1 | <1% |
Unknown | 198 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 43 | 21% |
Student > Postgraduate | 21 | 10% |
Researcher | 20 | 10% |
Student > Master | 20 | 10% |
Other | 19 | 9% |
Other | 38 | 19% |
Unknown | 40 | 20% |
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Psychology | 26 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 6% |
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Biochemistry, Genetics and Molecular Biology | 9 | 4% |
Other | 23 | 11% |
Unknown | 45 | 22% |