RT @YuyaT80811376: エンパグリフロジンやカナグリフロジン(カナグル®︎)には、健康な心臓への血管拡張作用の誘導が見られるとする一方、ダパグリフロジンには見られないとする報告もあります。 これらが、心不全の左室駆出率による適応申請の違いに現れている可能性があり…
RT @YuyaT80811376: @kentaron1971 僕も以前調べたことがあるのですが、利尿作用以外に心筋細胞に存在するNa+/H+交換輸送体の阻害作用など、複数の機序があるようです。 マウスレベルだとジャディアンス®︎には「健康な心臓への血管拡張作用」もあり(フ…
RT @YuyaT80811376: @kentaron1971 僕も以前調べたことがあるのですが、利尿作用以外に心筋細胞に存在するNa+/H+交換輸送体の阻害作用など、複数の機序があるようです。 マウスレベルだとジャディアンス®︎には「健康な心臓への血管拡張作用」もあり(フ…
RT @YuyaT80811376: @kentaron1971 僕も以前調べたことがあるのですが、利尿作用以外に心筋細胞に存在するNa+/H+交換輸送体の阻害作用など、複数の機序があるようです。 マウスレベルだとジャディアンス®︎には「健康な心臓への血管拡張作用」もあり(フ…
@kentaron1971 僕も以前調べたことがあるのですが、利尿作用以外に心筋細胞に存在するNa+/H+交換輸送体の阻害作用など、複数の機序があるようです。 マウスレベルだとジャディアンス®︎には「健康な心臓への血管拡張作用」もあり(フォシーガ®︎にはない)、それがHFpEFへの有効性に影響してるのかなと思ってました。
@captainchloride @NephroGuy @ASNKidney @Sglt2inhibitorL @ChristosArgyrop NHE1 in heart has been one of the purported mechanisms of action of heart protection https://t.co/iFPkL3jBI2
エンパグリフロジンやカナグリフロジン(カナグル®︎)には、健康な心臓への血管拡張作用の誘導が見られるとする一方、ダパグリフロジンには見られないとする報告もあります。 これらが、心不全の左室駆出率による適応申請の違いに現れている可能性がありますね。 cf. https://t.co/QSGozFzaPz
This paper shows that SGLT2 inhibitors inhibit NHE in mouse cardiomyocytes. Class Effects of SGLT2 Inhibitors in Mouse Cardiomyocytes and Hearts: Inhibition of Na +/H + Exchanger, Lowering of Cytosolic Na + and Vasodilation - PubMed https://t.co/fEROSyXGV
@GauravGulsin
In silico modelling of binding of SGLT2i to the cardiac sodium-hydrogen exchanger https://t.co/6cLZr4phkM https://t.co/tmUsvowTjt
Talking about this potentially significant off-target effect of sglt inhibitors on mouse myocytes #EndoTwitter https://t.co/XOYKMbN0rC
@EAllen0417 🐭 study: https://t.co/sHU0uwpBbG
the paper is here https://t.co/qW7kjsIUBh
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
The whispered drug development mantra-Always good to be lucky and often better lucky than good-does off target NHE modulation contribute to the wonderful effects of "selective" SGLT2 inhibitors #heartfailure #diabetes https://t.co/oGw8cbDoMq … https://t.co
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DanielJDrucker: The whispered drug development mantra-Always good to be lucky and often better lucky than good-does off target NHE modu…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
The whispered drug development mantra-Always good to be lucky and often better lucky than good-does off target NHE modulation contribute to the wonderful effects of "selective" SGLT2 inhibitors #heartfailure #diabetes https://t.co/uuk9felvLW
Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and empagliflozin may contribute to beneficial effects on heart failure. #heartfailure #SGLT2i https://t.co/zYIBS2wnEl 🔓 https://t.co/SRk2C6q
Does it offset fluid retaining effect of pioglitazone? What is 3ptMACE of double therapy. What about bladder and urinary tract? @BobRyderUK @DiabetesUK @ABCDiab https://t.co/jzP1kDg6v9
So it seems SGLT-2 inhibitors are not entirely specific to SGLT-2 after all. Maybe not so bad... In fact could be great! Exciting findings in mouse hearts could lead to new tx targets in #heart failure. Excited @tometergard? https://t.co/AvLzrcRaRm
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @AnastasiaSMihai: Class effect of SGLT2i to reducing [Na+]c https://t.co/gBMvcaHsP4
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
Class effect of SGLT2i to reducing [Na+]c https://t.co/gBMvcaHsP4
Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and empagliflozin may contribute to beneficial effects on heart failure. #heartfailure #SGLT2i https://t.co/zYIBS2eMfL 🔓 https://t.co/xNyHLQC
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
RT @DiabetologiaJnl: Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and…
Lowering of cardiac sodium and inhibition and binding of sodium-hydrogen exchanger by dapagliflozin, canagliflozin and empagliflozin may contribute to beneficial effects on heart failure. #heartfailure #SGLT2i https://t.co/zYIBS2wnEl 🔓 https://t.co/QUcVZ98
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @DanielJDrucker: Class Effect @DiabetologiaJnl Highly Selective Direct SGLT2i-Mediated High Affinity Inhibition of Cardiac NHE activity…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
RT @almucastro01: Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap http…
Efecto clase ISGLT2 en inhibición intercambio Na/H y otros efectos directos sobre corazones sanos: @cristinatejerap https://t.co/agbJPXZVhU
https://t.co/OTQTD5X3Nn @CardioIAN
RT @DanielJDrucker: Class Effect @DiabetologiaJnl Highly Selective Direct SGLT2i-Mediated High Affinity Inhibition of Cardiac NHE activity…
RT @AbdTahrani: Interesting insights into the mechanisms behind the cardiovascular benefits of SGLT2 inhibitors #diabetes https://t.co/etZk…
RT @DanielJDrucker: Class Effect @DiabetologiaJnl Highly Selective Direct SGLT2i-Mediated High Affinity Inhibition of Cardiac NHE activity…
RT @DanielJDrucker: Class Effect @DiabetologiaJnl Highly Selective Direct SGLT2i-Mediated High Affinity Inhibition of Cardiac NHE activity…
RT @AbdTahrani: Interesting insights into the mechanisms behind the cardiovascular benefits of SGLT2 inhibitors #diabetes https://t.co/etZk…
RT @AbdTahrani: Interesting insights into the mechanisms behind the cardiovascular benefits of SGLT2 inhibitors #diabetes https://t.co/etZk…
Interesting insights into the mechanisms behind the cardiovascular benefits of SGLT2 inhibitors #diabetes https://t.co/etZkkZfRg4
Class Effect @DiabetologiaJnl Highly Selective Direct SGLT2i-Mediated High Affinity Inhibition of Cardiac NHE activity (No SGLT2 in Heart) https://t.co/pnibRqp48w https://t.co/dhkx19Oa4W
【マウス】SGLT2阻害薬で、心筋細胞Na +/H+交.換輸送体活性抑制。心筋細胞内Na+濃度低下。 Diabetologia https://t.co/pvmqLu9Yev