Title |
LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma
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Published in |
SpringerPlus, November 2014
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DOI | 10.1186/2193-1801-3-661 |
Pubmed ID | |
Authors |
Shamsah Kazani, Jonathan P Arm, Joshua Boyce, Heng Chhay, Stefanie Dutile, Michael E Wechsler, Usha Govindarajulu, Priscilla Ivester, Hannah C Ainsworth, Susan Sergeant, Floyd H Chilton, Elliot Israel |
Abstract |
Botanical seed oils reduce the generation of leukotrienes in patients with asthma. Our objective was to determine the efficacy of a botanical seed oil combination against airflow obstruction in asthma, and to determine the pharmacogenomic effect of the leukotriene C4 synthase (LTC4S) polymorphism A-444C. We conducted a randomized, double-blind, placebo-controlled, cross-over clinical trial in mild to moderate asthmatics to determine the change in FEV1 after 6 weeks of therapy with borage and echium seed oils versus corn oil placebo. We also examined the effect of the variant LTC4S -444C allele on the change in lung function. We did not identify a difference in FEV1 in the study cohort as a whole (n = 28), nor in the group of A homozygotes. In the C allele carriers (n = 9), FEV1 improved by 3% after treatment with borage and echium seed oils and declined by 4% after placebo corn oil (p = 0.02). All 9 C allele carriers demonstrated an improvement in their FEV1 on active treatment compared to placebo as compared to only 7 out of 19 A allele homozygotes (p = 0.007). We observed transient differences in ex vivo leukotriene generation from circulating basophils and granulocytes. We did not observe significant differences in urinary LTE4 levels. We conclude that compared to corn oil, a combination of borage and echium seed oils improves airflow obstruction in mild to moderate asthmatics who carry the variant allele in the LTC4S gene (A-444C). Botanical oil supplementation may have therapeutic potential in asthma if used in a personalized manner. Trial registration: This trial was registered at http://www.clinicaltrials.gov as NCT00806442. |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 15 | 100% |
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Professor | 2 | 13% |
Lecturer > Senior Lecturer | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 1 | 7% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Unknown | 8 | 53% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Engineering | 1 | 7% |
Other | 0 | 0% |
Unknown | 9 | 60% |