| Title |
Role of Oct4 in the early embryo development
|
|---|---|
| Published in |
Cell Regeneration, April 2014
|
| DOI | 10.1186/2045-9769-3-7 |
| Pubmed ID | |
| Authors |
Guangming Wu, Hans R Schöler |
| Abstract |
Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs) or their differentiation into trophoblast. Oct4 of maternal origin is postulated to play critical role in defining totipotency and inducing pluripotency during embryonic development. However, the genetic elimination of maternal Oct4 using a Cre-lox approach in mouse revealed that the establishment of totipotency in maternal Oct4-depleted embryos was not affected, and that these embryos could complete full-term development without any obvious defect. These results indicate that Oct4 is not essential for the initiation of pluripotency, in contrast to its critical role in maintaining pluripotency. This conclusion is further supported by the formation of Oct4-GFP- and Nanog- expressing inner cell masses (ICMs) in embryos with complete inactivation of both maternal and zygotic Oct4 expression and the reprogramming of fibroblasts into fully pluripotent cells by Oct4-deficient oocytes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 292 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| Japan | 1 | <1% |
| Unknown | 289 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 50 | 17% |
| Student > Master | 48 | 16% |
| Student > Bachelor | 41 | 14% |
| Researcher | 38 | 13% |
| Student > Postgraduate | 18 | 6% |
| Other | 44 | 15% |
| Unknown | 53 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 98 | 34% |
| Agricultural and Biological Sciences | 78 | 27% |
| Medicine and Dentistry | 25 | 9% |
| Neuroscience | 7 | 2% |
| Chemistry | 3 | 1% |
| Other | 18 | 6% |
| Unknown | 63 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2023.
All research outputs
#2,959,476
of 25,374,917 outputs
Outputs from Cell Regeneration
#14
of 189 outputs
Outputs of similar age
#28,808
of 242,052 outputs
Outputs of similar age from Cell Regeneration
#1
of 4 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 189 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 93% of its peers.
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We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them