Title |
Zoledronic acid prevents decreases in bone mineral density in patients with prostate cancer undergoing combined androgen blockade
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Published in |
SpringerPlus, October 2014
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DOI | 10.1186/2193-1801-3-586 |
Pubmed ID | |
Authors |
Satoshi Nishizawa, Takeshi Inagaki, Akinori Iba, Kazuro Kikkawa, Yoshiki Kodama, Nagahide Matsumura, Yasuo Kohjimoto, Isao Hara |
Abstract |
The aim of this study was to evaluate the effect of zoledronic acid (ZA) on bone mineral density (BMD) in patients with prostate cancer receiving combined androgen blockade (CAB) as a first-line androgen deprivation therapy. Patients receiving CAB for prostate cancer without bone metastasis were candidates for this study. Forty-two patients were randomly assigned to receive either ZA or no treatment. BMD were measured at baseline and at 12 months. Bone-turnover markers, including cross-linked N-telopeptide of type I collagen (NTX), C-telopeptide of type I collagen (ICTP), and bone-specific alkaline phosphatase (BAP), were assessed during study periods. Patients on ZA maintained BMD after a year of treatment. Change in T-score from baseline differed significantly between the two groups (P=0.009). An inverse correlation was demonstrated between baseline and change in T-score in the ZA group. While ZA prevented an increase in ICTP and BAP, the increase in NTX was suppressed only in patients with low baseline T-score. ZA prevented a decrease in BMD in patients undergoing CAB, especially those with lower baseline BMD. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 67% |
Professor | 1 | 17% |
Researcher | 1 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 100% |