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Transcriptional and antioxidative responses to endogenous polyunsaturated fatty acid accumulation in yeast

Overview of attention for article published in Molecular and Cellular Biochemistry, October 2014
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Title
Transcriptional and antioxidative responses to endogenous polyunsaturated fatty acid accumulation in yeast
Published in
Molecular and Cellular Biochemistry, October 2014
DOI 10.1007/s11010-014-2229-6
Pubmed ID
Authors

Luka Andrisic, Emma J. Collinson, Oksana Tehlivets, Eleonora Perak, Tomislav Zarkovic, Ian W. Dawes, Neven Zarkovic, Ana Cipak Gasparovic

Abstract

Pathophysiology of polyunsaturated fatty acids (PUFAs) is associated with aberrant lipid and oxygen metabolism. In particular, under oxidative stress, PUFAs are prone to autocatalytic degradation via peroxidation, leading to formation of reactive aldehydes with numerous potentially harmful effects. However, the pathological and compensatory mechanisms induced by lipid peroxidation are very complex and not sufficiently understood. In our study, we have used yeast capable of endogenous PUFA synthesis in order to understand the effects triggered by PUFA accumulation on cellular physiology of a eukaryotic organism. The mechanisms induced by PUFA accumulation in S. cerevisiae expressing Hevea brasiliensis Δ12-fatty acid desaturase include down-regulation of components of electron transport chain in mitochondria as well as up-regulation of pentose-phosphate pathway and fatty acid β-oxidation at the transcriptional level. Interestingly, while no changes were observed at the transcriptional level, activities of two important enzymatic antioxidants, catalase and glutathione-S-transferase, were altered in response to PUFA accumulation. Increased intracellular glutathione levels further suggest an endogenous oxidative stress and activation of antioxidative defense mechanisms under conditions of PUFA accumulation. Finally, our data suggest that PUFA in cell membrane causes metabolic changes which in turn lead to adaptation to endogenous oxidative stress.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 32%
Student > Master 4 18%
Student > Bachelor 2 9%
Professor 2 9%
Student > Ph. D. Student 2 9%
Other 3 14%
Unknown 2 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 36%
Biochemistry, Genetics and Molecular Biology 5 23%
Nursing and Health Professions 1 5%
Business, Management and Accounting 1 5%
Computer Science 1 5%
Other 2 9%
Unknown 4 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2014.
All research outputs
#10,923,073
of 12,325,396 outputs
Outputs from Molecular and Cellular Biochemistry
#1,220
of 1,550 outputs
Outputs of similar age
#180,164
of 221,390 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#18
of 47 outputs
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