Title |
Post-Infectious Irritable Bowel Syndrome
|
---|---|
Published in |
Current Gastroenterology Reports, September 2017
|
DOI | 10.1007/s11894-017-0595-4 |
Pubmed ID | |
Authors |
Yeong Yeh Lee, Chandramouli Annamalai, Satish S. C. Rao |
Abstract |
Post-infectious irritable bowel syndrome (PI-IBS) is characterized by persistent abdominal pain and diarrhea, typically following an episode of infectious gastroenteritis. The mechanisms that underlie IBS-D remain elusive, but PI-IBS provides a mechanistic model of this disorder. This review provides an up-to-date appraisal of the pathophysiology, clinical features, and management approaches for PI-IBS. Disordered immune reactions and release of cytokines with resultant gut inflammation and dysfunction appear to be key features of PI-IBS. Disordered brain-gut-microbiota interactions, type of infecting agent, and host-genetic susceptibility are risk factors but also are reasons for the varying spectrum of clinical severity. Although prognosis is generally good, symptoms and inflammation may persist for a long time. Symptomatic relief with antidiarrheals, antispasmodics, 5HT3 antagonists, mesalamine, probiotics, and low-dose antidepressants remain the primary approaches, but in some difficult cases, a combination of drugs that target the pathophysiology may be helpful. PI-IBS has many overlapping features with IBS-D and shares similar pathophysiology and management approaches. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 25% |
United Kingdom | 1 | 13% |
Malaysia | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 63% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 79 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 15 | 19% |
Student > Bachelor | 11 | 14% |
Researcher | 9 | 11% |
Student > Ph. D. Student | 6 | 8% |
Other | 5 | 6% |
Other | 14 | 18% |
Unknown | 19 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 33% |
Nursing and Health Professions | 10 | 13% |
Agricultural and Biological Sciences | 6 | 8% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 9 | 11% |
Unknown | 22 | 28% |