Title |
New generation dendritic cell vaccine for immunotherapy of acute myeloid leukemia
|
---|---|
Published in |
Cancer Immunology, Immunotherapy, September 2014
|
DOI | 10.1007/s00262-014-1600-5 |
Pubmed ID | |
Authors |
Marion Subklewe, Christiane Geiger, Felix S. Lichtenegger, Miran Javorovic, Gunnar Kvalheim, Dolores J. Schendel, Iris Bigalke |
Abstract |
Dendritic cell (DC)-based immunotherapy is a promising strategy for the elimination of minimal residual disease in patients with acute myeloid leukemia (AML). Particularly, patients with a high risk of relapse who are not eligible for hematopoietic stem cell transplantation could benefit from such a therapeutic approach. Here, we review our extensive studies on the development of a protocol for the generation of DCs with improved immunogenicity and optimized for the use in cell-based immunotherapy. This new generation DC vaccine combines the production of DCs in only 3 days with Toll-like receptor-signaling-induced cell maturation. These mature DCs are then loaded with RNA encoding the leukemia-associated antigens Wilm's tumor protein 1 and preferentially expressed antigen in melanoma in order to stimulate an AML-specific T-cell-based immune response. In vitro as well as in vivo studies demonstrated the enhanced capacity of these improved DCs for the induction of tumor-specific immune responses. Finally, a proof-of-concept Phase I/II clinical trial is discussed for post-remission AML patients with high risk for disease relapse. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Unknown | 70 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 20% |
Student > Ph. D. Student | 12 | 17% |
Student > Bachelor | 8 | 11% |
Student > Doctoral Student | 7 | 10% |
Other | 7 | 10% |
Other | 15 | 21% |
Unknown | 8 | 11% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 27 | 38% |
Agricultural and Biological Sciences | 16 | 23% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Immunology and Microbiology | 5 | 7% |
Engineering | 3 | 4% |
Other | 2 | 3% |
Unknown | 13 | 18% |