Title |
The age-phenome database
|
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Published in |
SpringerPlus, April 2012
|
DOI | 10.1186/2193-1801-1-4 |
Pubmed ID | |
Authors |
Nophar Geifman, Eitan Rubin |
Abstract |
Data linking specific ages or age ranges with disease are abundant in biomedical literature. However, these data are organized such that searching for age-phenotype relationships is difficult. Recently, we described the Age-Phenome Knowledge-base (APK), a computational platform for storage and retrieval of information concerning age-related phenotypic patterns. Here, we report that data derived from over 1.5 million human-related PubMed abstracts have been added to APK. Using a text-mining pipeline, 35,683 entries which describe relationships between age and phenotype (such as disease) have been introduced into the database. Comparing the results to those obtained by a human reader reveals that the overall accuracy of these entries is estimated to exceed 80%. The usefulness of these data for obtaining new insight regarding age-disease relationships is demonstrated using clustering analysis, which is shown to capture obvious, as well as potentially interesting relationships between diseases. In addition, a new tool for browsing and searching the APK database is presented. We thus present a unique resource and a new framework for studying age-disease relationships and other phenotypic processes. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 14% |
Spain | 1 | 7% |
Netherlands | 1 | 7% |
Unknown | 10 | 71% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 2 | 14% |
Student > Ph. D. Student | 2 | 14% |
Other | 1 | 7% |
Student > Bachelor | 1 | 7% |
Professor | 1 | 7% |
Other | 3 | 21% |
Unknown | 4 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 29% |
Agricultural and Biological Sciences | 3 | 21% |
Computer Science | 1 | 7% |
Immunology and Microbiology | 1 | 7% |
Medicine and Dentistry | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 21% |