| Title |
Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling
|
|---|---|
| Published in |
Molecular and Cellular Pediatrics, October 2016
|
| DOI | 10.1186/s40348-016-0062-6 |
| Pubmed ID | |
| Authors |
Chiharu Ota, Hoeke A. Baarsma, Darcy E. Wagner, Anne Hilgendorff, Melanie Königshoff |
| Abstract |
Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood. |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 83 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 17% |
| Student > Bachelor | 13 | 16% |
| Student > Master | 9 | 11% |
| Researcher | 8 | 10% |
| Student > Doctoral Student | 4 | 5% |
| Other | 11 | 13% |
| Unknown | 24 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 22% |
| Medicine and Dentistry | 16 | 19% |
| Agricultural and Biological Sciences | 4 | 5% |
| Immunology and Microbiology | 4 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 7 | 8% |
| Unknown | 31 | 37% |