Title |
HIV and Stem Cell Transplantation
|
---|---|
Published in |
Current Infectious Disease Reports, August 2014
|
DOI | 10.1007/s11908-014-0424-y |
Pubmed ID | |
Authors |
Ignacio A. Echenique, George E. Nelson, Valentina Stosor, Christine M. Durand |
Abstract |
In human immunodeficiency virus (HIV)-infected persons, the incidence of hematologic malignancies, including leukemia and lymphoma, is increased despite the use of successful antiretroviral therapy. Hematopoietic stem cell transplantation (SCT) is emerging as a safe and effective therapy for HIV-infected persons with hematologic malignancies. Management of these patients is complicated by drug-drug interactions involving antiretroviral therapy (ART) that may impact conditioning agent efficacy and metabolism of immunosuppressive medications and potentiate drug toxicities. As such, optimal strategies for ART remain controversial. We discuss recent advances, controversies, and future directions related to SCT in HIV-infected persons, including the investigation of allogeneic SCT as a strategy for HIV cure. |
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Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 17% |
Researcher | 4 | 17% |
Student > Bachelor | 3 | 13% |
Student > Postgraduate | 3 | 13% |
Professor | 2 | 8% |
Other | 4 | 17% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 42% |
Nursing and Health Professions | 2 | 8% |
Agricultural and Biological Sciences | 2 | 8% |
Engineering | 2 | 8% |
Immunology and Microbiology | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 21% |