| Title |
An extracorporeal carbon dioxide removal (ECCO2R) device operating at hemodialysis blood flow rates
|
|---|---|
| Published in |
Intensive Care Medicine Experimental, September 2017
|
| DOI | 10.1186/s40635-017-0154-1 |
| Pubmed ID | |
| Authors |
R. Garrett Jeffries, Laura Lund, Brian Frankowski, William J. Federspiel |
| Abstract |
Extracorporeal carbon dioxide removal (ECCO2R) systems have gained clinical appeal as supplemental therapy in the treatment of acute and chronic respiratory injuries with low tidal volume or non-invasive ventilation. We have developed an ultra-low-flow ECCO2R device (ULFED) capable of operating at blood flows comparable to renal hemodialysis (250 mL/min). Comparable operating conditions allow use of minimally invasive dialysis cannulation strategies with potential for direct integration to existing dialysis circuitry. A carbon dioxide (CO2) removal device was fabricated with rotating impellers inside an annular hollow fiber membrane bundle to disrupt blood flow patterns and enhance gas exchange. In vitro gas exchange and hemolysis testing was conducted at hemodialysis blood flows (250 mL/min). In vitro carbon dioxide removal rates up to 75 mL/min were achieved in blood at normocapnia (pCO2 = 45 mmHg). In vitro hemolysis (including cannula and blood pump) was comparable to a Medtronic Minimax oxygenator control loop using a time-of-therapy normalized index of hemolysis (0.19 ± 0.04 g/100 min versus 0.12 ± 0.01 g/100 min, p = 0.169). In vitro performance suggests a new ultra-low-flow extracorporeal CO2 removal device could be utilized for safe and effective CO2 removal at hemodialysis flow rates using simplified and minimally invasive connection strategies. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 15% |
| Belgium | 3 | 9% |
| United Kingdom | 3 | 9% |
| United States | 3 | 9% |
| Italy | 2 | 6% |
| Venezuela, Bolivarian Republic of | 2 | 6% |
| New Zealand | 1 | 3% |
| Chile | 1 | 3% |
| Malaysia | 1 | 3% |
| Other | 4 | 12% |
| Unknown | 9 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 44% |
| Practitioners (doctors, other healthcare professionals) | 10 | 29% |
| Scientists | 5 | 15% |
| Science communicators (journalists, bloggers, editors) | 4 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 16% |
| Student > Ph. D. Student | 5 | 10% |
| Student > Bachelor | 4 | 8% |
| Student > Master | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Other | 11 | 22% |
| Unknown | 15 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 38% |
| Engineering | 5 | 10% |
| Nursing and Health Professions | 1 | 2% |
| Computer Science | 1 | 2% |
| Physics and Astronomy | 1 | 2% |
| Other | 5 | 10% |
| Unknown | 18 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2018.
All research outputs
#1,728,780
of 25,137,221 outputs
Outputs from Intensive Care Medicine Experimental
#46
of 528 outputs
Outputs of similar age
#33,081
of 321,130 outputs
Outputs of similar age from Intensive Care Medicine Experimental
#3
of 12 outputs
Altmetric has tracked 25,137,221 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 528 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,130 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.