@Dudebank @wrair @USAMMDA See this thread for context: https://t.co/A2qXvTkRPT
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
@arch2tch @srbaeksa @Dr_Camouflage_ @AustralianArmy @2GB873 @DVAAus @GSK @UniofOxford @NEJM @JaneCQuinn1 *CYP2D6 See also this paper from @WRAIR (developers of tafenoquine) in 2014 (yes, five years ago): https://t.co/zvbnxWjvjS
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
@APLMA_Malaria @LSHTM Now let's see a more honest appraisal of the efficacy and safety of tafenoquine, also dependent on CYP2D6 metabolism. Too many in the malaria community have irresponsibly touted tafenoquine as a wonder-drug, ignoring inconvenient fact
@HarryIWood @abcnews Unfortunately tafenoquine is ineffective for individuals with reduced CYP2D6 function, as is the case with primaquine. Tafenoquine is far from being the wonder-drug it is being touted to be. https://t.co/eL8DoZL3yD https://t.co/zvbnx
@UNITAID Please be aware that tafenoquine, as with primaquine, requires CYP2D6 metabolic activation for antimalarial efficacy. This is a major limitation for P. vivax elimination programs. https://t.co/1EhxjBo2PS https://t.co/cwBPWU9Bit https://t.co/Vvj4iC
RT @StuartMcCarthy_: The malaria research community continues to falsely promote tafenoquine as a "silver bullet" against P. vivax, ignorin…
RT @JaneCQuinn1: @GSK @TheWarriordoc @mefloq_vets_aus Will @AustralianArmy implement CYP2D6 testing prior to prescribing #tafenoquine for…
RT @StuartMcCarthy_: The malaria research community continues to falsely promote tafenoquine as a "silver bullet" against P. vivax, ignorin…
RT @StuartMcCarthy_: The malaria research community continues to falsely promote tafenoquine as a "silver bullet" against P. vivax, ignorin…
RT @StuartMcCarthy_: The malaria research community continues to falsely promote tafenoquine as a "silver bullet" against P. vivax, ignorin…
RT @StuartMcCarthy_: The malaria research community continues to falsely promote tafenoquine as a "silver bullet" against P. vivax, ignorin…
RT @StuartMcCarthy_: The malaria research community continues to falsely promote tafenoquine as a "silver bullet" against P. vivax, ignorin…
The malaria research community continues to falsely promote tafenoquine as a "silver bullet" against P. vivax, ignoring evidence of widespread treatment failures among trial subjects & published research on CYP2D6 metabolism/8-AQ efficacy. https://t.co
@PsychRecovery @CunliffeSue @LisaTra1 @DrTerryLynch @MHNurseLecturer @KellyMartin02 @Oona__Lehtinen @smile4wales @benzosarebad @rcpsych @ClinpsychLucy @dropthedisorder @APPGPDD @LizzieMBarnett @WEHI_research @AuSenate Note 4: Part of the "conspiracy theory
@journeyofdays Oddly enough it was @wrair scientists who discovered TQ is metabolised by CYP2D6. One responded by moving to @USAMMDA, negotiating the contract for 60 Degrees Pharma (incl the IP rights) to register TQ w @US_FDA, then retiring from @USArmy t
@hanniepower @MalariaJournal @NEJM Tafenoquine (primaquine analogue) also requires CYP2D6 metabolism for antimalarial efficacy. https://t.co/zvbnxWjvjS Baird et al estimate 38.8% of pop at risk of P vivax infection are intelligible for PQ due to G6PD def
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
RT @StuartMcCarthy_: @Standtofrankie @Reid99Mark @AustralianArmy @USArmy @US_FDA In the case of the 8-aminoquinolines (incl tafenoquine), w…
@Standtofrankie @Reid99Mark @AustralianArmy @USArmy @US_FDA In the case of the 8-aminoquinolines (incl tafenoquine), we already know that these drugs are not metabolised properly by those with reduced CYP2D6 function, up to 1/4 of some populations. https:/
RT @StuartMcCarthy_: @profamirattaran @ReedBeall Both tafenoquine & primaquine require activation by CYP2D6 for antimalarial efficacy, henc…
RT @StuartMcCarthy_: @profamirattaran @ReedBeall Both tafenoquine & primaquine require activation by CYP2D6 for antimalarial efficacy, henc…
@profamirattaran @ReedBeall Both tafenoquine & primaquine require activation by CYP2D6 for antimalarial efficacy, hence the similar treatment failure rates in this study, which also approximate to the prevalence of CYP2D6 poor and intermediate metaboli
RT @StuartMcCarthy_: @ricprice99 To make progress with P vivax, the malaria community needs to come to terms with the fact that the 8-amino…
RT @StuartMcCarthy_: @ricprice99 To make progress with P vivax, the malaria community needs to come to terms with the fact that the 8-amino…
RT @StuartMcCarthy_: @ricprice99 To make progress with P vivax, the malaria community needs to come to terms with the fact that the 8-amino…
@ricprice99 To make progress with P vivax, the malaria community needs to come to terms with the fact that the 8-aminoquinolines are ineffective for a large % of the population due to reduced CYP2D6 function. https://t.co/1EhxjBo2PS https://t.co/zvbnxWjvjS
@victoriahall26 @Cortes_Penfield Note that tafenoquine is ineffective against P vivax for CYP2D6 PMs & IMs. Myself and other @AustralianArmy tafenoquine subjects contracted vivax despite high dose tafenoquine (up to 1200mg over 3 days). https://t.co/u4
RT @StuartMcCarthy_: @DaveRimm @MedRecsUK @johndowe49 @RemingtonNevin @gatesfoundation @MedsforMalaria @GSK @BillGates Even if you ignore t…
RT @StuartMcCarthy_: @JaneCQuinn1 @DaveRimm @DrAseemMalhotra This is what Dr Dow's 60 Degrees chief medical officer Bryan Smith & colleague…
RT @StuartMcCarthy_: @JaneCQuinn1 @DaveRimm @DrAseemMalhotra This is what Dr Dow's 60 Degrees chief medical officer Bryan Smith & colleague…
@JaneCQuinn1 @DaveRimm @DrAseemMalhotra This is what Dr Dow's 60 Degrees chief medical officer Bryan Smith & colleagues at @wrair & @USAMMDA were saying about tafenoquine years ago: it doesn't work for 12-23% of the population. This drug is a fraud
RT @mefloq_vets_UK: @ArmyCGS @GavinWilliamson Keep an eye on this: it could come back and bite @DefenceHQ further down the line #Lariam #Me…
RT @StuartMcCarthy_: @JaneCQuinn1 @mefloq_vets_UK @mefloq_vets_aus @DaveRimm @johndowe49 @wrair Not to forget this research on tafenoquine…
RT @mefloq_vets_UK: @ArmyCGS @GavinWilliamson Keep an eye on this: it could come back and bite @DefenceHQ further down the line #Lariam #Me…
RT @StuartMcCarthy_: @JaneCQuinn1 @mefloq_vets_UK @mefloq_vets_aus @DaveRimm @johndowe49 @wrair Not to forget this research on tafenoquine…
@ArmyCGS @GavinWilliamson Keep an eye on this: it could come back and bite @DefenceHQ further down the line #Lariam #Mefloquine #tafenoquine @ArmySgtMajor @HMhelpforforces @MilitaryClaimUK @_TomKavanagh @BBCHughPym @katlay @BBCJoannaG @GenDonBolduc
RT @StuartMcCarthy_: @JaneCQuinn1 @mefloq_vets_UK @mefloq_vets_aus @DaveRimm @johndowe49 @wrair Not to forget this research on tafenoquine…
RT @StuartMcCarthy_: @JaneCQuinn1 @mefloq_vets_UK @mefloq_vets_aus @DaveRimm @johndowe49 @wrair Not to forget this research on tafenoquine…
RT @StuartMcCarthy_: @JaneCQuinn1 @mefloq_vets_UK @mefloq_vets_aus @DaveRimm @johndowe49 @wrair Not to forget this research on tafenoquine…
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
RT @StuartMcCarthy_: G6PD notwithstanding, the major limitation of the 8-aminoquinoline drugs #primaquine & #tafenoquine is that they requi…
RT @StuartMcCarthy_: G6PD notwithstanding, the major limitation of the 8-aminoquinoline drugs #primaquine & #tafenoquine is that they requi…
RT @StuartMcCarthy_: G6PD notwithstanding, the major limitation of the 8-aminoquinoline drugs #primaquine & #tafenoquine is that they requi…
RT @StuartMcCarthy_: G6PD notwithstanding, the major limitation of the 8-aminoquinoline drugs #primaquine & #tafenoquine is that they requi…
RT @StuartMcCarthy_: G6PD notwithstanding, the major limitation of the 8-aminoquinoline drugs #primaquine & #tafenoquine is that they requi…
RT @StuartMcCarthy_: G6PD notwithstanding, the major limitation of the 8-aminoquinoline drugs #primaquine & #tafenoquine is that they requi…
RT @StuartMcCarthy_: G6PD notwithstanding, the major limitation of the 8-aminoquinoline drugs #primaquine & #tafenoquine is that they requi…
G6PD notwithstanding, the major limitation of the 8-aminoquinoline drugs #primaquine & #tafenoquine is that they require activation by CYP2D6 for antimalarial efficacy: https://t.co/hMCnPqfSKq https://t.co/zvbnxWjvjS cc @JaneCQuinn1 https://t.co/c7f
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
RT @StuartMcCarthy_: @LalaSalter @CallThataCrisis @MikeKellyofEM I was given 1200mg of tafenoquine yet still contracted vivax malaria. This…
RT @StuartMcCarthy_: @LalaSalter @CallThataCrisis @MikeKellyofEM I was given 1200mg of tafenoquine yet still contracted vivax malaria. This…
@LalaSalter @CallThataCrisis @MikeKellyofEM I was given 1200mg of tafenoquine yet still contracted vivax malaria. This is because the 8-aminoquinolines require CYP2D6 metabolism for efficacy. Up to 1/4 of ADF personnel are CYP2D6 PMs or IMs, explaining hig
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
RT @StuartMcCarthy_: The @USAMMDA product manager for tafenoquine at this time is @USArmy Col. Bryan Smith, who had co-authored a paper on…
@vingreensill @vanbadham @Raymartin55 @CatherineDeveny @AustralianArmy @BillGates @GSK @USAMMDA @US_FDA Yes I totally agree. The other problem with tafenoquine is that it doesn't work for those of us with CYP2D6 deficiency, explaining why so many of us (my
RT @StuartMcCarthy_: @JaneCQuinn1 @mefloq_vets_UK @mefloq_vets_aus @DaveRimm @johndowe49 @wrair Not to forget this research on tafenoquine…
RT @StuartMcCarthy_: @JaneCQuinn1 @mefloq_vets_UK @mefloq_vets_aus @DaveRimm @johndowe49 @wrair Not to forget this research on tafenoquine…
@JaneCQuinn1 @mefloq_vets_UK @mefloq_vets_aus @DaveRimm @johndowe49 @wrair Not to forget this research on tafenoquine and CYP2D6 published four years ago by @wrair, whose staff now describe this as a "conspiracy theory". The fact that this drug does not wo
RT @StuartMcCarthy_: @wrair DYK the 8-aminoquinolines, including @wrair @gsk #60P tafenoquine (touted as the next P. vivax wonder drug), ar…
RT @StuartMcCarthy_: @wrair DYK the 8-aminoquinolines, including @wrair @gsk #60P tafenoquine (touted as the next P. vivax wonder drug), ar…
@wrair DYK the 8-aminoquinolines, including @wrair @gsk #60P tafenoquine (touted as the next P. vivax wonder drug), are ineffective for people with CYP2D6 deficiency, up to 1/4 of some populations? Of course you do. You published the research! https://t.co
@bbbrieger @InfectiousDz @PeterHotez The irony here is the strange reluctance on the part of the Malaria research community to accept the fact that the 8-aminoquinolines incl tafenoquine, touted as the new P vivax wonder drug, are ineffective for individua
RT @StuartMcCarthy_: @DaveRimm @MedRecsUK @johndowe49 @RemingtonNevin @gatesfoundation @MedsforMalaria @GSK @BillGates Even if you ignore t…
@GHhub @PLOSNTDs Tafenoquine is also: a) Ineffective against malaria in patients with reduced CYP2D6 function https://t.co/zvbnxWjvjS and b) Able to cause toxic encephalopathy https://t.co/9fLvfZ9mCD
RT @StuartMcCarthy_: @DaveRimm @MedRecsUK @johndowe49 @RemingtonNevin @gatesfoundation @MedsforMalaria @GSK @BillGates Even if you ignore t…
RT @StuartMcCarthy_: @DaveRimm @MedRecsUK @johndowe49 @RemingtonNevin @gatesfoundation @MedsforMalaria @GSK @BillGates Even if you ignore t…
RT @StuartMcCarthy_: @DaveRimm @MedRecsUK @johndowe49 @RemingtonNevin @gatesfoundation @MedsforMalaria @GSK @BillGates Even if you ignore t…
@mologic @PATHtweets What are the chances of developing a diagnostic for #CYP2D6 enzyme deficiency? The 8-aminoquinolines require activation by CYP2D6 to be effective against malaria. https://t.co/zvbnxWjvjS https://t.co/fvfwrCejqG
RT @StuartMcCarthy_: @DaveRimm @MedRecsUK @johndowe49 @RemingtonNevin @gatesfoundation @MedsforMalaria @GSK @BillGates Even if you ignore t…
@DaveRimm @MedRecsUK @johndowe49 @RemingtonNevin @gatesfoundation @MedsforMalaria @GSK @BillGates Even if you ignore the harm done by tafenoquine (Mefloquine 2.0), it doesn't even work for ppl with CYP2D6 deficiency, i.e. up to 1/4 of some populations. Man
@BillGates @GSK @MedsforMalaria @AustralianArmy Have @GSK and @MedsforMalaria told you that tafenoquine doesn't actually work for anywhere up to a quarter of the population? This is why so many if us contracted vivax malaria despite documented compliance d
RT @StuartMcCarthy_: When you have a few moments to spare from #betrootergate @M_McCormackMP, please implement CYP2D6 screening in #YourADF…
RT @StuartMcCarthy_: When you have a few moments to spare from #betrootergate @M_McCormackMP, please implement CYP2D6 screening in #YourADF…
RT @StuartMcCarthy_: When you have a few moments to spare from #betrootergate @M_McCormackMP, please implement CYP2D6 screening in #YourADF…
RT @StuartMcCarthy_: When you have a few moments to spare from #betrootergate @M_McCormackMP, please implement CYP2D6 screening in #YourADF…
RT @StuartMcCarthy_: When you have a few moments to spare from #betrootergate @M_McCormackMP, please implement CYP2D6 screening in #YourADF…
RT @StuartMcCarthy_: When you have a few moments to spare from #betrootergate @M_McCormackMP, please implement CYP2D6 screening in #YourADF…
When you have a few moments to spare from #betrootergate @M_McCormackMP, please implement CYP2D6 screening in #YourADF to prevent further suicides from quinoline antimalarials. Any questions, please ask leading world expert @JaneCQuinn1. Hint: she's one of
@GSK @TheWarriordoc @mefloq_vets_aus Will @AustralianArmy implement CYP2D6 testing prior to prescribing #tafenoquine for P. Vivax txt? Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for... https://t.co/giCpT
@dm_parker https://t.co/rZ9TbImktL @dm_parker please check this
RT @StuartMcCarthy_: @sanjeevneupane Unfortunately tafenoquine does not work in individuals with reduced CYP2D6 function (up to 1/4 of some…
RT @StuartMcCarthy_: @sanjeevneupane Unfortunately tafenoquine does not work in individuals with reduced CYP2D6 function (up to 1/4 of some…
RT @StuartMcCarthy_: @sanjeevneupane Unfortunately tafenoquine does not work in individuals with reduced CYP2D6 function (up to 1/4 of some…
Thanks for this information. I didn't know this. But despite all these shortcomings; TQ will be single dose and first new medicine for the Rx of P. vivax in last 60 years which I think would be more effective than PQ. https://t.co/25dOw6YNJd
@sanjeevneupane Unfortunately tafenoquine does not work in individuals with reduced CYP2D6 function (up to 1/4 of some populations), also known to be neurotoxic. https://t.co/zvbnxWjvjS https://t.co/9fLvfZ9mCD
@Fiddaman @GSK Unfortunately the new @GSK wonder drug - tafenoquine - doesn't work for up to 1/4 of the population. https://t.co/zvbnxWjvjS
@JaneCQuinn1 @Raymartin55 @RemingtonNevin @wrair @MedsforMalaria @US_FDA @GSK @AustralianArmy Also note how the 60P Chief Medical Officer (when he was a @USArmy @wrair employee) co-authored one of the early papers on CYP2D6 and 8-aminoquinoline treatment f