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Letter to the editor: is it valid to break down results from long-term trials in bipolar disorder by polarity of relapses?

Overview of attention for article published in International Journal of Bipolar Disorders, June 2014
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Title
Letter to the editor: is it valid to break down results from long-term trials in bipolar disorder by polarity of relapses?
Published in
International Journal of Bipolar Disorders, June 2014
DOI 10.1186/s40345-014-0008-7
Pubmed ID
Authors

Rasmus Wentzer Licht, Emanuel Severus

Abstract

When analysing and reporting data from long-term drug trials in bipolar disorder, it has become the standard to break down the outcome into the prevention of mania and the prevention of depression. However, as illustrated by a theoretical example, this approach may confer a potential analysis bias. The point is that when mania or depression, whatever appears first, is considered an endpoint, then an endpoint of mania will exclude an endpoint of depression and vice versa. The risk of such bias is reduced when the time course is taken into consideration in the analysis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Romania 1 17%
Unknown 5 83%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 33%
Student > Bachelor 1 17%
Researcher 1 17%
Student > Postgraduate 1 17%
Unknown 1 17%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Pharmacology, Toxicology and Pharmaceutical Science 1 17%
Chemistry 1 17%
Mathematics 1 17%
Unknown 1 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2015.
All research outputs
#14,657,412
of 23,577,654 outputs
Outputs from International Journal of Bipolar Disorders
#201
of 291 outputs
Outputs of similar age
#121,436
of 229,961 outputs
Outputs of similar age from International Journal of Bipolar Disorders
#1
of 3 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 291 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,961 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them