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Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause

Overview of attention for article published in Diabetologia, August 2008
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
7 tweeters
facebook
2 Facebook pages
q&a
2 Q&A threads
video
3 video uploaders

Citations

dimensions_citation
122 Dimensions

Readers on

mendeley
194 Mendeley
citeulike
4 CiteULike
Title
Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause
Published in
Diabetologia, August 2008
DOI 10.1007/s00125-008-1116-7
Pubmed ID
Authors

R. Taylor

Abstract

The metabolic abnormalities of type 2 diabetes can be reversed reproducibly by bariatric surgery. By quantifying the major pathophysiological abnormalities in insulin secretion and insulin action after surgery, the sequence of events leading to restoration of normal metabolism can be defined. Liver fat levels fall within days and normal hepatic insulin sensitivity is restored. Simultaneously, plasma glucose levels return towards normal. Insulin sensitivity of muscle remains abnormal, at least over the weeks and months after bariatric surgery. The effect of the surgery is explicable solely in terms of energy restriction. By combining this information with prospective observation of the changes immediately preceding the onset of type 2 diabetes, a clear picture emerges. Insulin resistance in muscle, caused by inherited and environmental factors, facilitates the development of fatty liver during positive energy balance. Once established, the increased insulin secretion required to maintain plasma glucose levels will further increase liver fat deposition. Fatty liver causes resistance to insulin suppression of hepatic glucose output as well as raised plasma triacylglycerol. Exposure of beta cells to increased levels of fatty acids, derived from circulating and locally deposited triacylglycerol, suppresses glucose-mediated insulin secretion. This is reversible initially, but eventually becomes permanent. The essential time sequence of the pathogenesis of type 2 diabetes is now evident. Muscle insulin resistance determines the rate at which fatty liver progresses, and ectopic fat deposition in liver and islet underlies the related dynamic defects of hepatic insulin resistance and beta cell dysfunction. These defects are capable of dramatic reversal under hypoenergetic feeding conditions, completely in early diabetes and to a worthwhile extent in more established disease.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Spain 2 1%
United Kingdom 2 1%
Netherlands 2 1%
Portugal 1 <1%
Denmark 1 <1%
Argentina 1 <1%
Canada 1 <1%
New Zealand 1 <1%
Other 0 0%
Unknown 180 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 44 23%
Researcher 28 14%
Student > Ph. D. Student 27 14%
Student > Bachelor 24 12%
Unspecified 14 7%
Other 57 29%
Readers by discipline Count As %
Medicine and Dentistry 82 42%
Agricultural and Biological Sciences 42 22%
Unspecified 22 11%
Nursing and Health Professions 16 8%
Biochemistry, Genetics and Molecular Biology 9 5%
Other 23 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2019.
All research outputs
#492,206
of 13,087,619 outputs
Outputs from Diabetologia
#326
of 3,794 outputs
Outputs of similar age
#8,653
of 188,695 outputs
Outputs of similar age from Diabetologia
#11
of 45 outputs
Altmetric has tracked 13,087,619 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,794 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,695 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.