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Vasculitis update: pathogenesis and biomarkers

Overview of attention for article published in Pediatric Nephrology, August 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

twitter
15 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
15 Dimensions

Readers on

mendeley
60 Mendeley
Title
Vasculitis update: pathogenesis and biomarkers
Published in
Pediatric Nephrology, August 2017
DOI 10.1007/s00467-017-3597-4
Pubmed ID
Authors

Paul Brogan, Despina Eleftheriou

Abstract

Better understanding of the pathogenesis and treatment of primary systemic vasculitides (PSV) has led to the development of many potentially clinically relevant biomarkers. Genome-wide association studies have highlighted that MHC class II polymorphisms may influence the development of particular anti-neutrophil cytoplasmic antibody (ANCA) serotypes, but not the clinical phenotype of ANCA-associated vasculitis (AAV). Although ANCAs are overall poor biomarkers of disease activity, they may be useful for the prediction of flares of renal and/or pulmonary vasculitis. Moreover, patients with proteinase 3 (PR3)-AAV may respond better to rituximab than cyclophosphamide. Newer biomarkers of renal vasculitis in AAV include urinary soluble CD163, and may in the future reduce the requirement for renal biopsy. Better understanding of dysregulated neutrophil activation in AAV has led to the identification of novel biomarkers including circulating microparticles, and neutrophil extracellular traps (NETs), although their clinical utility has not yet been realised. Studies examining endothelial injury and repair responses have additionally revealed indices that may have utility as disease activity and/or prognostic biomarkers. Last, next-generation sequencing technologies are revealing monogenic forms of vasculitis, such as deficiency of adenosine deaminase type 2 (DADA2), and are profoundly influencing the approach to the diagnosis and treatment of vasculitis in the young.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 17%
Researcher 8 13%
Student > Doctoral Student 5 8%
Student > Master 5 8%
Student > Ph. D. Student 5 8%
Other 12 20%
Unknown 15 25%
Readers by discipline Count As %
Medicine and Dentistry 34 57%
Unspecified 2 3%
Biochemistry, Genetics and Molecular Biology 2 3%
Agricultural and Biological Sciences 1 2%
Nursing and Health Professions 1 2%
Other 4 7%
Unknown 16 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2018.
All research outputs
#2,293,664
of 13,987,764 outputs
Outputs from Pediatric Nephrology
#228
of 2,196 outputs
Outputs of similar age
#60,807
of 268,571 outputs
Outputs of similar age from Pediatric Nephrology
#9
of 75 outputs
Altmetric has tracked 13,987,764 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,196 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,571 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.