| Title |
Internal exposure to neutron-activated 56Mn dioxide powder in Wistar rats—Part 2: pathological effects
|
|---|---|
| Published in |
Radiation and Environmental Biophysics, February 2017
|
| DOI | 10.1007/s00411-016-0676-z |
| Pubmed ID | |
| Authors |
Kazuko Shichijo, Nariaki Fujimoto, Darkhan Uzbekov, Ynkar Kairkhanova, Aisulu Saimova, Nailya Chaizhunusova, Nurlan Sayakenov, Dariya Shabdarbaeva, Nurlan Aukenov, Almas Azimkhanov, Alexander Kolbayenkov, Zhanna Mussazhanova, Daisuke Niino, Masahiro Nakashima, Kassym Zhumadilov, Valeriy Stepanenko, Masao Tomonaga, Tolebay Rakhypbekov, Masaharu Hoshi |
| Abstract |
To fully understand the radiation effects of the atomic bombing of Hiroshima and Nagasaki among the survivors, radiation from neutron-induced radioisotopes in soil and other materials should be considered in addition to the initial radiation directly received from the bombs. This might be important for evaluating the radiation risks to the people who moved to these cities soon after the detonations and probably inhaled activated radioactive "dust." Manganese-56 is known to be one of the dominant radioisotopes produced in soil by neutrons. Due to its short physical half-life, (56)Mn emits residual radiation during the first hours after explosion. Hence, the biological effects of internal exposure of Wistar rats to (56)Mn were investigated in the present study. MnO2 powder was activated by a neutron beam to produce radioactive (56)Mn. Rats were divided into four groups: those exposed to (56)Mn, to non-radioactive Mn, to (60)Co γ rays (2 Gy, whole body), and those not exposed to any additional radiation (control). On days 3, 14, and 60 after exposure, the animals were killed and major organs were dissected and subjected to histopathological analysis. As described in more detail by an accompanying publication, the highest internal radiation dose was observed in the digestive system of the rats, followed by the lungs. It was found that the number of mitotic cells increased in the small intestine on day 3 after (56)Mn and (60)Co exposure, and this change persisted only in (56)Mn-exposed animals. Lung tissue was severely damaged only by exposure to (56)Mn, despite a rather low radiation dose (less than 0.1 Gy). These data suggest that internal exposure to (56)Mn has a significant biological impact on the lungs and small intestine. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 9% |
| United States | 1 | 9% |
| Japan | 1 | 9% |
| Unknown | 8 | 73% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 29% |
| Professor > Associate Professor | 2 | 14% |
| Student > Master | 2 | 14% |
| Student > Ph. D. Student | 1 | 7% |
| Professor | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 4 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 2 | 14% |
| Medicine and Dentistry | 2 | 14% |
| Linguistics | 1 | 7% |
| Physics and Astronomy | 1 | 7% |
| Computer Science | 1 | 7% |
| Other | 2 | 14% |
| Unknown | 5 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2023.
All research outputs
#6,534,339
of 25,756,531 outputs
Outputs from Radiation and Environmental Biophysics
#100
of 487 outputs
Outputs of similar age
#112,040
of 426,838 outputs
Outputs of similar age from Radiation and Environmental Biophysics
#3
of 6 outputs
Altmetric has tracked 25,756,531 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 487 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 426,838 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.