↓ Skip to main content

Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Overview of attention for article published in European Journal of Epidemiology, May 2014
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)

Mentioned by

twitter
4 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
43 Mendeley
Title
Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
Published in
European Journal of Epidemiology, May 2014
DOI 10.1007/s10654-014-9901-8
Pubmed ID
Authors

Krasimira Aleksandrova, Mazda Jenab, H. Bas Bueno-de-Mesquita, Veronika Fedirko, Rudolf Kaaks, Annekatrin Lukanova, Fränzel J. B. van Duijnhoven, Eugene Jansen, Sabina Rinaldi, Isabelle Romieu, Pietro Ferrari, Neil Murphy, Marc J. Gunter, Elio Riboli, Sabine Westhpal, Kim Overvad, Anne Tjønneland, Jytte Halkjær, Marie-Christine Boutron-Ruault, Laure Dossus, Antoine Racine, Antonia Trichopoulou, Christina Bamia, Philippos Orfanos, Claudia Agnoli, Domenico Palli, Salvatore Panico, Rosario Tumino, Paolo Vineis, Petra H. Peeters, Eric J. Duell, Esther Molina-Montes, J. Ramón Quirós, Miren Dorronsoro, Maria-Dolores Chirlaque, Aurelio Barricarte, Ingrid Ljuslinder, Richard Palmqvist, Ruth C. Travis, Kay-Tee Khaw, Nicholas Wareham, Tobias Pischon, Heiner Boeing

Abstract

A number of biomarkers of inflammatory and metabolic pathways are individually related to higher risk of colorectal cancer (CRC); however, the association between biomarker patterns and CRC incidence has not been previously evaluated. Our study investigates the association of biomarker patterns with CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). During median follow-up time of 7.0 (3.7-9.4) years, 1,260 incident CRC cases occurred and were matched to 1,260 controls using risk-set sampling. Pre-diagnostic measurements of C-peptide, glycated hemoglobin, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), reactive oxygen metabolites (ROM), insulin-like growth factor 1, adiponectin, leptin and soluble leptin receptor (sOB-R) were used to derive biomarker patterns from principal component analysis (PCA). The relation with CRC incidence was assessed using conditional logistic regression models. We identified four biomarker patterns 'HDL-C/Adiponectin fractions', 'ROM/CRP', 'TG/C-peptide' and 'leptin/sOB-R' to explain 60 % of the overall biomarker variance. In multivariable-adjusted logistic regression, the 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' patterns were associated with CRC risk [for the highest quartile vs the lowest, incidence rate ratio (IRR) = 0.69, 95 % CI 0.51-0.93, P-trend = 0.01; IRR = 1.70, 95 % CI 1.30-2.23, P-trend = 0.002; and IRR = 0.79, 95 % CI 0.58-1.07; P-trend = 0.05, respectively]. In contrast, the 'TG/C-peptide' pattern was not associated with CRC risk (IRR = 0.75, 95 % CI 0.56-1.00, P-trend = 0.24). After cases within the first 2 follow-up years were excluded, the 'ROM/CRP' pattern was no longer associated with CRC risk, suggesting potential influence of preclinical disease on these associations. By application of PCA, the study identified 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' as biomarker patterns representing potentially important pathways for CRC development.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 2 5%
Finland 1 2%
United States 1 2%
Canada 1 2%
Unknown 38 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 19%
Student > Ph. D. Student 8 19%
Student > Master 7 16%
Student > Postgraduate 5 12%
Professor 4 9%
Other 11 26%
Readers by discipline Count As %
Medicine and Dentistry 17 40%
Nursing and Health Professions 6 14%
Unspecified 4 9%
Biochemistry, Genetics and Molecular Biology 3 7%
Agricultural and Biological Sciences 3 7%
Other 10 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2017.
All research outputs
#6,656,636
of 12,327,627 outputs
Outputs from European Journal of Epidemiology
#734
of 1,054 outputs
Outputs of similar age
#75,780
of 197,871 outputs
Outputs of similar age from European Journal of Epidemiology
#18
of 26 outputs
Altmetric has tracked 12,327,627 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,054 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,871 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.