Title |
MicroRNAs in Allergy and Asthma
|
---|---|
Published in |
Current Allergy and Asthma Reports, February 2014
|
DOI | 10.1007/s11882-014-0424-x |
Pubmed ID | |
Authors |
Ana Rebane, Cezmi A. Akdis |
Abstract |
microRNAs (miRNAs) are short, single-stranded RNA molecules that function together with the partner proteins and cause degradation of target mRNAs or inhibit their translation. A particular miRNA can have hundreds of targets; therefore, miRNAs cumulatively influence the expression of a large proportion of genes. The functions of miRNAs in human diseases have been studied since their discovery in mammalian cells approximately 12 years ago. However, the role of miRNAs in allergic disease has only very recently begun to be uncovered. The purpose of this review is to provide an overview of the functions of miRNAs involved in the development of allergic diseases. We describe here the functions of miRNAs that regulate Th2 polarization and influence general inflammatory and tissue responses. In addition, we will highlight findings about the functions of extracellular miRNAs as possible noninvasive biomarkers of diseases with heterogeneous phenotypes and complex mechanisms and briefly discuss advances in the development of miRNA-based therapeutics. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 1% |
Brazil | 1 | 1% |
United Kingdom | 1 | 1% |
Spain | 1 | 1% |
United States | 1 | 1% |
Unknown | 65 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 24% |
Researcher | 12 | 17% |
Student > Doctoral Student | 6 | 9% |
Student > Bachelor | 6 | 9% |
Professor > Associate Professor | 4 | 6% |
Other | 12 | 17% |
Unknown | 13 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 30% |
Biochemistry, Genetics and Molecular Biology | 11 | 16% |
Medicine and Dentistry | 8 | 11% |
Immunology and Microbiology | 6 | 9% |
Nursing and Health Professions | 2 | 3% |
Other | 4 | 6% |
Unknown | 18 | 26% |