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Significance of long chain polyunsaturated fatty acids in human health

Overview of attention for article published in Clinical and Translational Medicine, July 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#23 of 513)
  • High Attention Score compared to outputs of the same age (91st percentile)

Mentioned by

2 news outlets
1 blog
1 policy source
5 tweeters
1 Facebook page


222 Dimensions

Readers on

371 Mendeley
Significance of long chain polyunsaturated fatty acids in human health
Published in
Clinical and Translational Medicine, July 2017
DOI 10.1186/s40169-017-0153-6
Pubmed ID

Rafael Zárate, Nabil Jaber‐Vazdekis, Noemi Tejera, José A. Pérez, Covadonga Rodríguez


In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid metabolism, together with their involvement in the occurrence of human disease. Of particular interest is the study of omega-3 and omega-6 long chain polyunsaturated fatty acids (LC-PUFAs), notably EPA (eicosapentaenoic acid, 20:5n-3), DHA (docosahexaenoic acid, 22:6n-3), and ARA (arachidonic acid, 20:4n-6), and their transformation into bioactive lipid mediators. In this sense, new families of PUFA-derived lipid mediators, including resolvins derived from EPA and DHA, and protectins and maresins derived from DHA, are being increasingly investigated because of their active role in the "return to homeostasis" process and resolution of inflammation. Recent findings reviewed in the present study highlight that the omega-6 fatty acid ARA appears increased, and omega-3 EPA and DHA decreased in most cancer tissues compared to normal ones, and that increments in omega-3 LC-PUFAs consumption and an omega-6/omega-3 ratio of 2-4:1, are associated with a reduced risk of breast, prostate, colon and renal cancers. Along with their lipid-lowering properties, omega-3 LC-PUFAs also exert cardioprotective functions, such as reducing platelet aggregation and inflammation, and controlling the presence of DHA in our body, especially in our liver and brain, which is crucial for optimal brain functionality. Considering that DHA is the principal omega-3 FA in cortical gray matter, the importance of DHA intake and its derived lipid mediators have been recently reported in patients with major depressive and bipolar disorders, Alzheimer disease, Parkinson's disease, and amyotrophic lateral sclerosis. The present study reviews the relationships between major diseases occurring today in the Western world and LC-PUFAs. More specifically this review focuses on the dietary omega-3 LC-PUFAs and the omega-6/omega-3 balance, in a wide range of inflammation disorders, including autoimmune diseases. This review suggests that the current recommendations of consumption and/or supplementation of omega-3 FAs are specific to particular groups of age and physiological status, and still need more fine tuning for overall human health and well being.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 371 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 371 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 56 15%
Student > Ph. D. Student 54 15%
Student > Master 51 14%
Researcher 45 12%
Student > Doctoral Student 17 5%
Other 55 15%
Unknown 93 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 56 15%
Agricultural and Biological Sciences 52 14%
Medicine and Dentistry 37 10%
Neuroscience 23 6%
Nursing and Health Professions 19 5%
Other 65 18%
Unknown 119 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2022.
All research outputs
of 19,982,192 outputs
Outputs from Clinical and Translational Medicine
of 513 outputs
Outputs of similar age
of 284,845 outputs
Outputs of similar age from Clinical and Translational Medicine
of 1 outputs
Altmetric has tracked 19,982,192 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 513 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,845 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them