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Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype

Overview of attention for article published in Acta Neuropathologica, September 2006
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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86 Mendeley
Title
Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype
Published in
Acta Neuropathologica, September 2006
DOI 10.1007/s00401-006-0138-9
Pubmed ID
Authors

Ian R. A. Mackenzie, Atik Baborie, Stuart Pickering-Brown, Daniel Du Plessis, Evelyn Jaros, Robert H. Perry, David Neary, Julie S. Snowden, David M. A. Mann

Abstract

We have investigated the extent and pattern of immunostaining for ubiquitin protein (UBQ) in 60 patients with frontotemporal lobar degeneration (FTLD) with ubiquitin-positive, tau-negative inclusions (FTLD-U), 37 of whom were ascertained in Manchester UK and 23 in Newcastle-Upon-Tyne, UK. There were three distinct histological patterns according to the form and distribution of the UBQ pathology. Histological type 1 was present in 19 patients (32%) and characterised by the presence of a moderate number, or numerous, UBQ immunoreactive neurites and intraneuronal cytoplasmic inclusions within layer II of the frontal and temporal cerebral cortex, and cytoplasmic inclusions within granule cells of the dentate gyrus; neuronal intranuclear inclusions (NII) of a "cat's eye" or "lentiform" appearance were present in 17 of these patients. In histological type 2 (16 patients, 27%), UBQ neurites were predominantly, or exclusively, present with few intraneuronal cytoplasmic inclusions within layer II of the cerebral cortex, while in histological type 3 (25 patients, 42%), UBQ intraneuronal cytoplasmic inclusions either within the cortical layer II or in the granule cells of the dentate gyrus, with few or no UBQ neurites, were seen. In neither of these latter two groups were NII present. The influence of histological type on clinical phenotype was highly significant with type 1 histology being associated clinically with cases of frontotemporal dementia (FTD) or progressive non-fluent aphasia (PNFA), type 2 histology with semantic dementia (SD), and type 3 histology with FTD, or FTD and motor neurone disease (MND).

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 2%
United Kingdom 2 2%
United States 2 2%
Japan 1 1%
Czechia 1 1%
Unknown 78 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 23 27%
Student > Ph. D. Student 18 21%
Student > Bachelor 11 13%
Other 6 7%
Student > Master 6 7%
Other 22 26%
Readers by discipline Count As %
Medicine and Dentistry 40 47%
Agricultural and Biological Sciences 15 17%
Neuroscience 12 14%
Unspecified 10 12%
Psychology 5 6%
Other 4 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2009.
All research outputs
#956,983
of 4,681,163 outputs
Outputs from Acta Neuropathologica
#192
of 601 outputs
Outputs of similar age
#11,915
of 54,704 outputs
Outputs of similar age from Acta Neuropathologica
#3
of 7 outputs
Altmetric has tracked 4,681,163 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 601 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 54,704 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.