Title |
Complete resection for pleomorphic lung cancer with a high serum IL-6 level: a case report
|
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Published in |
Surgical Case Reports, September 2016
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DOI | 10.1186/s40792-016-0232-8 |
Pubmed ID | |
Authors |
Soichi Oka, Hiroki Matsumiya, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Naoko Imanishi, Koji Kuroda, Hidetaka Uramoto, Fumihiro Tanaka |
Abstract |
Pleomorphic lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. Recently, the autonomous production of hematopoietic cytokines (granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor [GM-CSF], and interleukin-6 [IL-6]) was observed in some of these patients. We herein report a case of complete resection of right pleomorphic lung cancer producing IL-6. The patient had a high-grade fever before surgery, and a blood examination showed high IL-6 and CRP levels in the serum. After surgery, the patient no longer had a fever, and the elevated serum IL-6 levels had dropped to values less than those before the operation. Immunohistochemically, the carcinoma cells were faintly or focally positive for IL-6 and negative for G-CSF. The symptoms in the present case were dramatically improved by surgery. In addition, an immunohistochemical examination showed that the cancer cells were positive for IL-6. |
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