| Title |
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld’s syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry
|
|---|---|
| Published in |
Clinical Rheumatology, July 2017
|
| DOI | 10.1007/s10067-017-3748-9 |
| Pubmed ID | |
| Authors |
Abdulla Watad, Mariana Quaresma, Nicola Luigi Bragazzi, Ricard Cervera, Jan Willem Cohen Tervaert, Howard Amital, Yehuda Shoenfeld |
| Abstract |
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a recently identified condition in which the exposure to an adjuvant leads to an aberrant autoimmune response. We aimed to summarize the results obtained from the ASIA syndrome registry up to December 2016, in a descriptive analysis of 300 cases of ASIA syndrome, with a focus on the adjuvants, the clinical manifestations, and the relationship with other autoimmune diseases. A Web-based registry, based on a multicenter international study, collected clinical and laboratory data in a form of a questionnaire applied to patients with ASIA syndrome. Experts in the disease validated all cases independently. A comparison study regarding type of adjuvants and differences in clinical and laboratory findings was performed. Three hundred patients were analyzed. The mean age at disease onset was 37 years, and the mean duration of time latency between adjuvant stimuli and development of autoimmune conditions was 16.8 months, ranging between 3 days to 5 years. Arthralgia, myalgia, and chronic fatigue were the most frequently reported symptoms. Eighty-nine percent of patients were also diagnosed with another defined rheumatic/autoimmune condition. The most frequent autoimmune disease related to ASIA syndrome was undifferentiated connective tissue disease (UCTD). ASIA syndrome is associated with a high incidence of UCTD and positive anti-nuclear antibodies (ANA) test. Clinical and laboratory features differ from the type of adjuvant used. These findings may contribute to an increased awareness of ASIA syndrome and help physicians to identify patients at a greater risk of autoimmune diseases following the exposure to vaccines and other adjuvants. The ASIA syndrome registry provides a useful tool to systematize this rare condition. |
X Demographics
The data shown below were collected from the profiles of 127 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 25 | 20% |
| Canada | 4 | 3% |
| Italy | 3 | 2% |
| Argentina | 3 | 2% |
| Australia | 3 | 2% |
| Switzerland | 2 | 2% |
| Belgium | 1 | <1% |
| United Kingdom | 1 | <1% |
| Ireland | 1 | <1% |
| Other | 5 | 4% |
| Unknown | 79 | 62% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 109 | 86% |
| Practitioners (doctors, other healthcare professionals) | 12 | 9% |
| Scientists | 3 | 2% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 153 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 26 | 17% |
| Researcher | 24 | 16% |
| Student > Bachelor | 14 | 9% |
| Other | 12 | 8% |
| Student > Master | 12 | 8% |
| Other | 30 | 20% |
| Unknown | 35 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 78 | 51% |
| Nursing and Health Professions | 8 | 5% |
| Psychology | 7 | 5% |
| Biochemistry, Genetics and Molecular Biology | 3 | 2% |
| Agricultural and Biological Sciences | 2 | 1% |
| Other | 11 | 7% |
| Unknown | 44 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 136. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2024.
All research outputs
#315,199
of 25,931,626 outputs
Outputs from Clinical Rheumatology
#19
of 3,330 outputs
Outputs of similar age
#6,560
of 331,450 outputs
Outputs of similar age from Clinical Rheumatology
#2
of 52 outputs
Altmetric has tracked 25,931,626 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,330 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 99% of its peers.
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